Rate of Malignant Transformation and Clinical Characteristics Among an Oral Lichen Planus Cohort: a Retrospective Center Experience

Launched by CATHOLIC UNIVERSITY OF THE SACRED HEART · Apr 12, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a condition called oral lichen planus (OLP), which is a long-term inflammatory condition affecting the lining of the mouth. The main goal of the study is to find out how often OLP can change into a more serious condition, like oral cancer. Researchers also want to learn more about the characteristics of people with OLP to identify any risk factors that might make this transformation more likely. Additionally, the study will look at how effective different treatments for OLP are.

To participate in this trial, individuals must have a confirmed diagnosis of oral lichen planus and be willing to allow their personal data to be used for research. Participants should also be able to commit to at least six months of follow-up. People with certain conditions, like other types of oral lesions or a history of specific medical treatments, are not eligible. If you join this study, you can expect to be monitored over time to see how your condition develops and to receive treatment options that may help manage your symptoms.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Clinical-histological diagnosis of Oral lichen planus
• • Patients who gave consensus to personal data treatment
• • Minimum 6 months follow-up
• Exclusion Criteria:
• • Patients who did not give consensus to personal data treatment
• • Oral lichenoid lesions
• • Patients with anamnesis of hematopoietic stem cells transplant
• • Patients with a OSCC at the first histological examination (i.e., namely: also OSCC patients with a OLP background were excluded)