Types of Intracellular Bacteria in Atherosclerotic Plaques and Analysis of Risk Factors

Launched by TANG-DU HOSPITAL · Apr 11, 2025

Keywords

ClinConnect Summary

This clinical trial, called iBacAP, is looking into the types of bacteria found inside the carotid plaques of patients with a condition known as atherosclerosis, which can narrow the arteries in the neck. The researchers want to understand what types of bacteria are present in these plaques and if certain types are linked to worse health outcomes for patients. They will study patients with various levels of artery narrowing and examine whether the specific bacteria they have affects their overall health and recovery.

To participate in this trial, individuals must have been diagnosed with significant narrowing of the carotid arteries and have experienced related health events, like a stroke or a mini-stroke. Participants will not receive any new treatments or interventions but will continue with their usual care. The study aims to include both men and women aged between 65 and 74. It’s important to note that people with certain health conditions, such as severe respiratory diseases or advanced cancers, and those who are pregnant or currently involved in other clinical studies, will not be eligible to join.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • All enrolled patients were diagnosed with clear head and neck artery stenosis and a risk event after head and neck revascularization;
• • Location of lesion: origin of internal carotid artery, bifurcation of internal and external carotid arteries;
• • Patients with symptomatic head and neck artery stenosis and dangerous events after head and neck blood flow reconstruction, and with a degree of stenosis ≥ 70% on non-invasive examination or stenosis ≥ 50% found on angiography;
• • Asymptomatic head and neck artery stenosis and risk events after head and neck revascularization, with a degree of stenosis ≥ 70% on non-invasive examination or stenosis ≥ 60% found on angiography;
• • Asymptomatic head and neck artery stenosis and dangerous events after head and neck blood flow reconstruction, with a non-invasive examination of stenosis degree less than 70%, but angiography or other examinations indicate that the stenosis lesion is in an unstable state;
• • Symptomatic head and neck artery stenosis and risk events after head and neck revascularization, non-invasive examination of head and neck artery stenosis and risk event degree after head and neck revascularization at 50% to 69%
• Exclusion Criteria:
• • Patients with poor overall condition and intolerance to general anesthesia;
• • Patients with mental illness or severe mental illness;
• • Severe respiratory system diseases;
• • Pregnant and lactating women;
• • Participating in another clinical study;
• • Patients with advanced tumors or those who are expected to die within one year;