Oral Melatonin VS Nebulized Dexmedetomidine Premedication on Attenuation of Hemodynamic Response to Direct Laryngoscopy and Tracheal Intubation in Hypertensive Patients

Launched by TANTA UNIVERSITY · Apr 11, 2025

Keywords

ClinConnect Summary

This clinical trial is studying two different medications, oral melatonin and nebulized dexmedetomidine, to see which one helps reduce the body's stress responses during a procedure called laryngoscopy and tracheal intubation in patients with controlled high blood pressure. These procedures are often performed when patients are put under general anesthesia for elective surgeries. The goal is to find out which medication can help make the process smoother and safer for patients.

To participate in this study, you need to be between 40 and 60 years old, have controlled high blood pressure, and be in good overall health (classified as ASA physical status II). If you are interested in joining, you'll need to undergo an elective surgery under general anesthesia. However, certain conditions, such as a high body mass index (BMI), heart problems, or being pregnant, would prevent you from taking part in the trial. If you do join, you can expect to receive either melatonin or dexmedetomidine before your procedure, and the researchers will monitor how your body responds. Keep in mind that this study is not yet recruiting participants, so there will be more information available once it starts.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age (40-60) years of both genders.
• • Controlled hypertensive patients.
• • Categorized as ASA physical status II.
• • Planning to do an elective surgery under General Anesthesia.
• Exclusion Criteria:
• • Patient refusal to participate in the study.
• • Patient with expected difficult intubation.
• • Body Mass Index (BMI) \> 30 kg/m2.
• • History of allergy to the drugs of the study.
• • Patients with Heart rate\<50 or Heart block.
• • End stage renal and hepatic disease.
• • Patients on beta blocker, oral hypoglycemics, anti-depressants, anti-convulsants, anti- psychotics and thyroid medications.
• • Pregnant or lactating females.