Jack Jumper Ant Venom Immunotherapy Long-term Effectiveness Investigation

Launched by MURDOCH CHILDRENS RESEARCH INSTITUTE · Apr 13, 2025

Keywords

ClinConnect Summary

The Jack Jumper Ant Venom Immunotherapy Long-term Effectiveness Investigation is a clinical trial looking at how effective a specific treatment is for people who are allergic to the venom of Jack Jumper ants. This allergy is common in Australia, affecting about 3% of the population, and many people who are allergic may experience serious reactions if stung again. The trial aims to learn more about the long-term benefits of venom immunotherapy (VIT), which helps prevent severe allergic reactions, and how it affects quality of life after patients have completed their treatment.

To participate in this trial, adults aged 18 and older must have completed a VIT program for at least 3 years but less than 6 years and have been off the treatment for at least 18 months but less than 5 years. Participants will undergo a controlled sting challenge to see how well they tolerate the venom and will answer questions about their experiences and quality of life. This information will help researchers understand the lasting effects of the treatment and how it influences patients' lives, especially regarding their awareness and use of auto-injectors for allergic reactions.

Gender

ALL

Eligibility criteria

• • Eligibility criteria
• • - Any adult (≥ 18 years) who has completed a JJA VIT program at one of the three participating sites.
• Inclusion Criteria:
• • 1. Completed a continuous program of JJA VIT of between 3 and \< 6 years duration.
• • 2. Have ceased JJA VIT for ≥ 18 months but \< 5 years.
• • 3. Have the ability to provide informed consent.
• Exclusion Criteria:
• • 1. Any person \< 18 years.
• • 2. Any adult (≥ 18 years) who has not completed a continuous JJA VIT program of duration between 3 and \< 6 years.
• • 3. Any adult (≥ 18 years) who has completed a continuous JJA VIT program of duration between 3 and \< 6 years but ceased JJA VIT \< 18 months or \> 5 years ago.
• • 4. Any person who has a medical condition, that in the opinion of the investigator, may place them at increased risk if they were to have a sting challenge.
• • 5. Unable to understand study requirements and provide informed consent.