Comparison of 40% Glucose Solution and Autologous Blood Patch Pleurodesis for Postoperative Air Leak After Lung Resections

Launched by WIELKOPOLSKIE CENTRUM PULMONOLOGII I TORAKOCHIRURGII · Apr 16, 2025

Keywords

ClinConnect Summary

This clinical trial is studying two different treatments for a condition called prolonged air leak (PAL), which can happen after lung surgery. PAL occurs when air leaks out from the lung into the space around it, which can cause discomfort and delay recovery. The trial is comparing the effectiveness of a treatment using a 40% glucose solution with a method that uses the patient’s own blood to seal the air leak. Both methods aim to help patients heal faster and improve their quality of life after surgery.

To be eligible for the trial, participants must be at least 18 years old and have undergone specific lung surgeries, such as lobectomy, at a designated hospital. They should also have a diagnosed PAL that has lasted longer than five days after surgery. Participants will receive either the glucose solution treatment or the blood patch treatment, and the trial aims to see which method works better in closing the air leak. It's important to note that the trial is currently recruiting participants, and anyone interested will need to provide informed consent and meet certain health criteria. Overall, this study could lead to better treatment options for patients recovering from lung surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age: patients aged 18 years or older.
• • Surgical Procedure: patients who underwent anatomical lung resections (segmentectomy, lobectomy, or bilobectomy) at the Department of Thoracic Surgery, Poznan University of Medical Sciences, between November 2023 and December 2024.
• • Prolonged Air Leak Diagnosis: patients with diagnosed PAL after lung resection, as defined by air leakage persisting beyond 5 days post-surgery.
• • Consent: patients who were willing to provide informed consent for participation in the study and for the intervention procedures (autologous blood pleurodesis or 40% glucose solution pleurodesis).
• Exclusion Criteria:
• • Non-Anatomical Resections: Patients who underwent non-anatomical resections, such as pneumonectomy, lung transplantation, sleeve resections, or wedge resections.
• • Patients from whom the required volume of peripheral blood (120 ml) could not be collected.
• • Active Infection or Sepsis: Patients with ongoing infections or sepsis at the time of enrollment.
• • Reoperation or Additional Interventions: patients who required immediate reoperation or other interventions that disturb the process of treating PAL.
• • Mental Health or Cognitive Impairment: patients with significant cognitive impairments or mental health conditions that hinder the ability to provide informed consent or comply with study procedures.
• • Patients who failed to perform three ABPP or 40% glucose injections (no consent, need for urgent surgery).