Efficacy and Safety of Cold Versus Hot Snare Polypectomy for Removal of 4-10 mm Pedunculated Colorectal Polyps

Launched by SHANDONG UNIVERSITY · Apr 17, 2025

Keywords

ClinConnect Summary

This clinical trial is studying two different methods for removing certain types of growths called pedunculated colorectal polyps, which are small, mushroom-shaped lumps that can develop in the colon. The researchers want to find out if using a “cold” method is just as effective and safe as a “hot” method for taking these polyps out. They will specifically look at how often patients experience bleeding after the procedure, along with other factors like how quickly the procedure can be done and how completely the polyp is removed.

To participate in this trial, you need to be between 18 and 80 years old and have at least one of these polyps that is 4-10 mm in size detected during a colonoscopy, which is a procedure to examine the colon. However, some people may not be eligible, such as those with certain health conditions or who are taking specific medications. If you join the trial, you will receive either the cold or hot method for polypectomy (the term for polyp removal), and the study will keep track of your recovery and any possible complications. This research aims to improve how these procedures are done to help patients have safer and better outcomes.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. 18-80 years old, male and female
• • 2. Proposed colonoscopy and colonoscopy detection of at least one 4-10 mm pedunculated colorectal polyp
• Exclusion Criteria:
• • 1. Contraindication to colonoscopy or polypectomy
• • 2. Use of antiplatelet or anticoagulant drugs within 1 week before polypectomy
• • 3. Alarming signs and symptoms of colorectal cancer (blood in stool, black stool, unexplained anaemia and weight loss, abdominal mass, positive rectal examination; or imaging and laboratory tests highly suspicious for colorectal cancer) or endoscopic manifestations of polyps highly suspicious for high-grade intraepithelial neoplasia or carcinoma
• • 4. Comorbidity with inflammatory bowel disease, colonic polyposis, or active gastrointestinal bleeding
• • 5. Inadequate bowel preparation
• • 6. Pregnant or lactating women
• • 7. Failure to sign the informed consent form
• • 8. Patients deemed ineligible by investigators to enrol in the trial