Effect of Genetic Polymorphisms on Response to Preoperative NSAIDs in Endodontic Postoperative Pain Management

Launched by ATATURK UNIVERSITY · Apr 14, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how our genes can affect how well certain pain medications work for managing pain after dental procedures like root canals. Specifically, the researchers want to see if taking non-steroidal anti-inflammatory drugs (NSAIDs) before the procedure helps with pain relief and how individual genetic differences might play a role in this. Participants will receive standard pain medication before their treatment, and their pain levels will be measured afterward. The goal is to find better ways to tailor pain management based on a person's unique genetic makeup.

To be eligible for this study, participants should be between 18 and 65 years old and have specific dental issues, like having a painful tooth that needs treatment. It’s important that they do not have any serious health problems or certain dental conditions that could complicate the study. Those who join the trial can expect to receive standard care for their dental treatment while helping researchers learn more about how genetics can influence pain management. This study is currently looking for volunteers, and everyone, regardless of gender, is welcome to participate.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patients aged between 18 and 65 years
• • 2. Vital mandibular molar teeth diagnosed with symptomatic apical periodontitis
• • 3. ASA physical status classification I or II
• • 4. Preoperative VAS pain score greater than 50
• • 5. No known genetic disorders (e.g., Down syndrome, congenital insensitivity to pain)
• Exclusion Criteria:
• • 1. Patients classified as ASA III or higher
• • 2. Pregnant women or those suspected of being pregnant
• • 3. Presence of root canal curvature greater than 25° (Schilder classification)
• • 4. Patients with generalized periodontitis
• • 5. Presence of periodontal pockets deeper than 3 mm in the affected tooth
• • 6. History of systemic disease or known allergies
• • 7. Patients with diagnosed psychiatric or psychological disorders
• • 8. Presence of swelling, sinus tract, or preoperative tenderness on palpation
• • 9. Patients with bruxism
• • 10. Presence of resorption in the affected tooth
• • 11. Use of analgesic or anti-inflammatory drugs within 12 hours prior to the procedure
• • 12. Teeth with root fractures, ankylosis, or pathological mobility