Effects of Environmental Heat Exposure on Human Multiple Organ Function

Launched by YINAN QU · Apr 14, 2025

Keywords

ClinConnect Summary

This clinical trial is investigating how exposure to high temperatures affects different organs in the body and how this might lead to heat-related health issues. The researchers want to understand the immediate effects of heat on people’s bodies, which can help in managing conditions like heat stress or organ dysfunction.

To participate in this study, you need to be a healthy Chinese adult between 18 and 30 years old, able to read and understand Chinese, and living in Jinan during the study. There are specific health criteria you must meet, such as having a normal body mass index and lung function. If you are currently taking medications that might affect your body temperature, have certain health conditions, or are pregnant or breastfeeding, you may not be eligible to join. If you participate, you can expect to be part of a controlled environment where researchers will monitor your body’s response to heat exposure, helping them learn more about how heat impacts health.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Chinese nationality（aged 18-30 years healthy males and females）;
• • 2. With ability to read and understand Chinese smoothly;
• • 3. Living in Jinan during the study period;
• • 4. Body mass index ≥ 18.5 and ≤ 28;
• • 5. Normal resting ECG；
• • 6. Normal lung function: i. Forced vital capacity (FVC)≥80% of that predicted for gender, ethnicity, age and height; ii. Forced expiratory volume in one second (FEV1) ≥80% of that predicted for gender, ethnicity, age and height; iii. FEV1/FVC ratio≥80% of predicted values.
• Exclusion Criteria:
• • 1. Medications or dietary supplements intake that may alter body temperature during the study period;
• • 2. Individuals who have unspecified illnesses, which in the judgment of the investigators might increase the risk associated with heat exposure will be a basis for exclusion;
• • 3. Subjects with anemia, needle fainting and other signs unsuitable for blood drawing；
• • 4. Subjects with cardiovascular diseases or other chronic medical condition, such as congenital heart disease, pulmonary heart disease, and hypertension, etc;
• • 5. Subjects with a history of major cardio-vascular, respiratory, or nervous system surgery, etc;
• • 6. Subjects with neurologic disorders, such as stroke, traumatic brain injury, epilepsy, and depression;
• • 7. Subjects with allergic diseases, such as allergic rhinitis and allergic asthma, etc;
• • 8. Subjects are pregnant, attempting to become pregnant or breastfeeding;
• • 9. Subjects who are currently smoking (including vaping, hookah and e-cigarette) or have smoking history within 1 year of study (defined as more than 1 pk/yr in the past year) or have a greater than equal to a 5 pack year smoking history;
• • 10. Subjects living with a smoker who smokes inside the house;
• • 11. Subjects who are current drinking or have frequent alcohol use (defined as at least 1 time per week) in the past 6 months;
• • 12. Provisional exclusion criteria, such as acute infection in the past two weeks or taking antibiotics. (Subjects can be enrolled after 2 weeks)