Evaluating the Efficacy of Topical Insulin for the Restoration of Ocular Surface Interface in Dry Eye Disease.

Launched by KHYBER TEACHING HOSPITAL · Apr 15, 2025

Keywords

ClinConnect Summary

This clinical trial is studying the effectiveness of insulin eye drops as a treatment for moderate to severe dry eye disease. Researchers want to see if these insulin drops can improve the health of the surface of the eye better than regular artificial tears. The trial will last for one year and is currently looking for participants aged 18 and older, regardless of gender. To qualify, participants must have specific test results indicating they have dry eye disease, such as low tear production.

If you decide to participate, you will be randomly assigned to receive either insulin eye drops or artificial tears, and your eye health will be monitored over the year. It's important to note that individuals with certain conditions, like active eye infections or those who have had eye surgery in the past six months, will not be eligible for this trial. This study aims to find a new and effective way to help people who suffer from dry eye disease, potentially improving their daily comfort and quality of life.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients having Schirmer's test values of less than 10mm after 5 minutes of the procedure recording plus a non-invasive tear breakup time (TBUT) of less than 10 seconds and the Ocular Surface Disease Index (OSDI) of more than 32 (diagnosed as dry eye disease as per the operational definition of this study).
• • any gender.
• • aged 18 years and above.
• Exclusion Criteria:
• • Patients with active ocular infection, severe ocular surface disease other than Dry eye disease, and those who have undergone ocular surgery within the past 6 months.
• • Under 18 years old