Cardiometabolic evalUation REgistry of Heart Failure

Launched by RUIJIN HOSPITAL · Apr 18, 2025

Keywords

ClinConnect Summary

This clinical trial, called the Cardiometabolic Evaluation Registry of Heart Failure, is studying how different health factors related to metabolism and heart function affect patients with heart failure. Heart failure is a condition where the heart doesn’t pump blood as well as it should. The researchers want to understand how things like cholesterol levels, blood sugar, and fat around the heart can influence heart structure and function over time. They will look at patients with various types of heart failure and follow them for five years to see how their health changes and if they experience any serious heart-related events.

To participate in this trial, you need to be at least 18 years old and have chronic heart failure, which includes different categories based on how well your heart is functioning. Some examples include patients with reduced heart function or those whose heart function has improved. However, if you have a serious illness that might limit your survival to less than a year or if you're pregnant, you would not be eligible to join. If you decide to participate, you’ll help researchers gather important information that could lead to better, personalized treatments for heart failure in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age ≥ 18 years
• 2. Chronic HF (NYHA II\~IV), including:
• • HFrEF (HF with reduced ejection fraction): ① HF symptoms±signs ; ② LVEF≤40%.
• • HFimpEF (HF with improved ejection fraction): ① HF symptoms±signs; ② previous LVEF ≤ 40% and a follow-up measurement of LVEF \>40%.
• • HFmrEF (HF with mildly reduced ejection fraction): ① HF symptoms±signs; ② LVEF 41%\~49%.
• • HFpEF (HF with preserved ejection fraction): ① HF symptoms±signs; ② LVEF ≥50%; ③ objective evidence of cardiac structural and/or functional abnormalities consistent with the presence of LV diastolic dysfunction/raised LV filling pressures, including raised natriuretic peptide.
• Exclusion Criteria:
• • 1. Estimated survival ≤ 1 year.
• • 2. Pregnant or lactation, or have the intention to give birth within one year.
• • 3. Poor compliance, unable to follow-up.
• • 4. Mental or physical status not allowing written informed consent.
• • 5. Unwillingness to give informed consent.