Pregnancy Registry, Infants, Serum/Milk Analysis (PRISMA)

Launched by UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · Apr 15, 2025

Keywords

ClinConnect Summary

The PRISMA study is a research project that aims to gather important information about pregnancy in women who have certain chronic neurological conditions, like Multiple Sclerosis and Myasthenia Gravis. The goal is to understand how these conditions and their treatments affect both mothers and their babies. Women who are pregnant, planning to become pregnant, or who have recently given birth can participate. The study is open to women aged 18 to 64, and it's fully remote, meaning you can take part from home.

Participants will have the option to provide various samples, like blood or breast milk, at specific times during their pregnancy or after giving birth. There are also online surveys to complete. It’s important to note that participation in sample collection is completely optional, and for blood tests, you can arrange for a professional to come to your home. This study is designed to help improve the understanding of pregnancy in women with these conditions, ultimately aiming to enhance maternal and infant health.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Pregnant or contemplating pregnancy
• • Female, aged 18 to 64 years
• * Diagnosis of one of the following conditions:
• • Clinically Isolated Syndrome (CIS) or Multiple Sclerosis (MS), based on the 2010 McDonald Criteria
• • Neuromyelitis Optica Spectrum Disorder (NMOSD)
• • Inflammatory Bowel Disease (IBD)
• • Rheumatoid Arthritis (RA)
• • Myasthenia Gravis
• • Lupus
• • Other chronic neurological conditions
• • Willing to provide biosamples and/or complete surveys at specified timepoints
• • Women without a chronic condition who are pregnant or contemplating pregnancy (as part of the control group)
• Exclusion Criteria:
• • - Unwillingness to provide informed consent