High Resolution Gastric Mapping and Gastroduodenal Manometry

Launched by MAYO CLINIC · Apr 15, 2025

Keywords

ClinConnect Summary

This clinical trial is investigating a condition called dyspepsia, which is a common digestive issue characterized by symptoms like stomach pain, bloating, and discomfort. The researchers aim to better understand the causes of dyspepsia by examining how the stomach moves and functions. They will look at how symptoms relate to stomach emptying and other activities in the stomach. Currently, there are no FDA-approved medications specifically for dyspepsia, so the goal is to find safe and effective ways to treat it.

To participate in this study, individuals aged 18 to 75 who have experienced symptoms of dyspepsia for at least six months may be eligible. However, those with certain heart conditions or other serious health issues that could affect their safety or the study’s results will not be able to join. Participants will undergo tests to measure their gastric function and will be monitored throughout the process. This research hopes to lead to better treatments for dyspepsia in the future.

Gender

ALL

Eligibility criteria

• • Inclusion Criteria
• • Symptoms consistent with functional dyspepsia as defined by the ROME IV criteria for 6 months
• • Ability to perform appropriate informed consent
• • Exclusion Criteria
• • Known cardiac arrhythmia or major ECG abnormalities, i.e. cardiac conduction disturbances (2nd or 3rd degree AV block, prolonged QTc interval (\> 460 msec) or bradycardia (\< 45 beats/minute)
• • Conditions precluding safe use of taVNS
• • Clinical evidence of significant cardiovascular, respiratory, renal, hepatic, gastrointestinal, hematological, neurological, psychiatric or other disease that may interfere with the objectives of the study and/or pose safety concerns
• • Use of opioids
• • Vulnerable study population
• • Pregnant women