Elucidating Hepatic Metabolism in Non-alcoholic Fatty Liver Disease

Launched by HELSINKI UNIVERSITY CENTRAL HOSPITAL · Apr 16, 2025

Keywords

ClinConnect Summary

In this study the investigators study the metabolic adaptations underlying the progression of nonalcoholic fatty liver disease (NAFLD), namely hepatic mitochondrial reductive stress, ureagenesis, de novo lipogenesis and gluconeogenesis in patients with advanced and mild NAFLD and in healthy controls.

At the first visit, an informed consent will be obtained, followed by assessment of inclusion/exclusion criteria and medical history. Participants fulfilling the criteria will be enrolled in the study. A physical examination will be performed and laboratory test will be taken. Body composition...

Gender

ALL

Eligibility criteria

• The following inclusion/ exclusion criteria will be employed:
• • 1. Participants must be able to communicate meaningfully with the investigator and must be legally competent to provide written informed consent.
• • 2. Subject must be likely to be available to complete all protocol-required study visits or procedures, to the best of the subject's and investigator's knowledge.
• • 3. Participants must be aged between 18-75 years.
• • 4. Participants are not allowed to have alcohol consumption of 350 g/week or more in women and 420 g/week or more in men.
• • 5. Participants are not allowed to have history of liver disease other than NAFLD as judged by history and physical examination and standard laboratory tests.
• • 6. Participants are not allowed to have claustrophobia or metal implants to allow magnetic resonance studies.
• • 7. Participants are not allowed to be pregnant or lactating.
• • 8. No known or anticipated difficulties in cannulation of peripheral veins.
• • 9. No history or evidence of any other clinically significant disorder, condition or disease other than those outlined above that, in the opinion of the investigator may compromise the ability of the subject to give written informed consent, would pose a risk to subject safety, or interfere with the study evaluation, procedures or completion.