Determination of the Optimal Volume of Liposomal Bupivacaine in Adductor Canal Block for Knee Joint Surgery

Launched by NANJING FIRST HOSPITAL, NANJING MEDICAL UNIVERSITY · Apr 17, 2025

Keywords

ClinConnect Summary

This clinical trial is investigating the best amount of a medication called liposomal bupivacaine to use during a specific pain relief procedure for patients undergoing knee surgery. The goal is to find the right dose that provides effective pain control while minimizing side effects. This study is unique because it uses advanced methods to carefully evaluate how different doses affect pain relief, which could lead to more personalized and effective pain management for knee surgery patients.

To participate in this trial, you need to be between 18 and 65 years old and scheduled for knee surgery that requires general anesthesia. You should also be in good health, without serious medical issues like diabetes or a history of chronic pain. If you decide to join, you will help researchers understand how to better manage pain after knee surgery, which could benefit future patients. It's important to note that people with certain medical conditions or allergies may not be eligible for this study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients undergoing elective general anesthesia for unilateral knee joint surgery.
• • Patients who provide informed consent.
• • Aged between 18 and 65 years old, regardless of gender.
• • American Society of Anesthesiologists (ASA) physical status classification of Ⅰ to Ⅲ
• • Body mass index (BMI) ≤ 35 kg/m².
• Exclusion Criteria:
• • Femoral neuropathy.
• • Coagulation dysfunction.
• • Allergy to local anesthetics.
• • Infection at the puncture site.
• • History of chronic pain or opioid use.
• • Pregnancy.
• • Diabetes mellitus and peripheral neuropathy.