A Study to Evaluate the Efficacy and Safety of Treatment With CsA-PG Ophthalmic Gel in Dry Eye Patients

Launched by ZHAOKE (GUANGZHOU) OPHTHALMOLOGY PHARMACEUTICAL LTD. · Apr 16, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at a new eye gel called CsA-PG Ophthalmic Gel to see how well it works for people suffering from dry eye disease. The study is designed to compare this new gel with an existing treatment, CsA Ophthalmic Gel, to confirm that it is safe and effective in easing dry eye symptoms. The trial will take place at multiple locations and will involve adults aged 18 and older who have been experiencing dry eye symptoms for at least six months.

To participate, individuals will need to have a specific diagnosis of dry eye disease and meet certain health criteria. Some key points for eligibility include not having any significant eye diseases or infections, not using certain medications or treatments that could interfere with the study, and being willing to comply with study requirements. Participants can expect to attend several visits for assessments and receive the study treatment, helping researchers learn more about the best ways to manage dry eye symptoms.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Be at least 18 years of age, male or female;
• • 2. Provide written informed consent;
• • 3. Have a reported history of dry eye for at least 6 months before Visit 1;
• • 4. Have a clinical diagnosis of bilateral dry eye disease, including all of the following scored in at least one eye at both Visits 1 and 2;
• • 1. Corneal fluorescein staining score in either inferior, superior, or central zone ≥ 2
• • 2. Schirmer Tear Test score (STT, anesthetized) of ≤ 10 mm and ≥ 1 mm
• • 3. Have an Eye Dryness Score (EDS; Visual Analogue scale, VAS) ≤80 and ≥40
• Exclusion Criteria:
• • 1. Clinical diagnosis or history of any clinically significant ocular diseases/disorders (e.g., age-related maculopathy that requires treatment and/or in the opinion of the Investigator may interfere with study parameters in Visit 1 and/or Visit 2;
• • 2. Any active ocular or systemic infection (e.g., bacterial, viral, or fungal) at Visit 1 and/or Visit 2;
• • 3. Any active ocular inflammation (e.g., iritis, uveitis, allergic conjunctivitis) at Visit 1 and/or Visit 2;
• • 4. Any conjunctival scarring history (Such as with irradiation, alkali burns, Steven Johnson syndrome, Sjogren's syndrome, cicatricial pemphigoid) or destruction of conjunctival goblet cells (e.g., neurotrophic keratitis, vitamin A deficiency) before Visit 1;
• • 5. Have worn contact lenses within 14 days of Visit 1 or anticipate using contact lenses during the study;
• • 6. Have any refractive surgery and/or any other ocular surgical procedure within 3 months before Visit 1; or have any ocular surgical procedure scheduled to be conducted during the study period;
• • 7. Have eyelid surgery within 6 months before Visit 1 or planned eyelid surgery during the study period;
• • 8. Have Nd:YAG (neodymium-doped yttrium aluminum garnet) laser capsulotomy within 6 months before Visit 1;
• • 9. Have used temporary (i.e., collagen) punctual plugs within 3 months before Visit 1 or anticipate their use during the study period;
• • 10. Have permanent punctual plugs inserted or have surgical punctual occlusion before Visit 1 or anticipate any such event during the study period;
• • 11. Use any of the following treatments in the period indicated before Visit 1 or anticipate their use at any time during the study.
• Topical medications（30 days prior to Visit 1）:
• • Restasis®, Cequa™, Tyrvaya, Eysuvis, Xiidra
• • Topical ophthalmic non-steroidal anti-inflammatories
• • Topical ophthalmic corticosteroids
• • Topical ophthalmic autologous serum Exceptions: demulcent ophthalmic drops (e.g., OCCT artificial tears) may be used until Screen Visit 1, but these must be discontinued after screening.
• Systemic medication (30 days before Visit 1):
• Any systemic medication known to cause ocular drying (e.g., antidepressants, beta blockers) except if it was taken on a stable dosing regimen for at least 30 days before Visit 1 and is expected to be taken on the same regimen throughout the study period. The known systemic medications that can cause ocular drying include:
• • antihistamines, antidepressants, bronchodilators, antiarrhythmics
• • anti-Parkinson's disease drugs, antipsychotics, antitussives, anticongestants
• • adrenoceptor blockers, thiazide diuretics, anti-leprosy drugs, antimalarials, antineoplastics anxiolytics/sleeping agents, herbs and vitamins, calcium modulators
• • Corticosteroids (e.g., systemic steroids including intravenous, intramuscular, intraarticular, and oral steroids; facial topical steroids; dermatological steroids with high potency or large treatment areas)
• • Cyclosporine and any other immunosuppressor
• • Other medications that can impact dry eye disease favorably or not include various analgesics, including opiates, cannabinoids, omega-3 dietary supplements, and other agents. Such meds should be continued on study only if that represents a continuation of an unavoidable and unchanged regimen of treatment for a disease that is not otherwise excluded
• Non-medicine treatment (30 days before Visit 1):
• • LipiFlow® or other similar meibomian gland dysfunction (MGD) therapy;
• • Eye mask with heat or steam and any other warming method of the eyelid (e.g., warm towel application);
• • Intense pulsed light treatment;
• • Bandage contact lenses or scleral contact lenses;
• • Route eyelid cleaning;
• • Any other treatment that will relieve dry eye symptoms and signs.
• • 12. Have a severe/serious systemic disease, chronic illness, or uncontrolled medical condition including, but not limited to, severe cardiopulmonary disease, poorly controlled hypertension, poorly controlled diabetes, and/or clinically significant (CS) hematologic, renal, or liver disease that in the opinion of the Investigator could interfere with study assessments or limit compliance;
• • 13. Be a woman who is pregnant, nursing, or planning a pregnancy;
• • 14. Be unwilling to submit a urine pregnancy test at Visit 1 and Visit 5 (or early termination visit) if of childbearing potential. The non-childbearing potential is defined as a woman who is permanently sterilized (e.g., has had a hysterectomy, bilateral tubal ligation, or bilateral oophorectomy) or is post-menopausal (i.e., without menses for 12 consecutive months);
• • 15. Be a woman of childbearing potential who is not using an acceptable means of birth control during the study period and 30 days after the end of the study. Acceptable methods of contraception include hormonal (e.g., oral, implantable, injectable, or transdermal contraceptives), mechanical (e.g., spermicide in conjunction with a barrier such as a diaphragm or a condom), intrauterine device (IUD), or surgical sterilization of partner. For non-sexually active females, abstinence might be regarded as an adequate method of birth control; however, if the subject becomes sexually active during the study, she must agree to use acceptable birth control as defined above for the remainder of the study;
• • 16. Have a known hypersensitivity or contraindication to the investigational products (IPs) or their components;
• • 17. Have a condition or be in a situation that the Investigator felt may put the subject at significant risk, may confound the study results, or may interfere significantly with the subject's participation in the study (e.g., any planned procedure or surgery during the study period);
• • 18. Be currently enrolled in an investigational drug or device study or have used an investigational drug or device within 30 days before Visit 1;
• • 19. In the opinion of the Investigator, be unable or unwilling to comply with the study protocol, including participation in all study assessments, visits, and dosing, or be unable to instill eye drops successfully.