Effect of Serum Vitamin D on MARPE Treatment Response

Launched by KONYA NECMETTIN ERBAKAN ÜNIVERSITESI · Apr 16, 2025

Keywords

ClinConnect Summary

This randomized clinical trial aims to evaluate the potential impact of serum vitamin D levels on the outcomes of Miniscrew-Assisted Rapid Palatal Expansion (MARPE) treatment in young adults aged 15-18 years. A total of 30 patients presenting with maxillary transverse deficiency will be recruited during the first half of 2025. Patients will be randomly allocated to two groups. The intervention group will undergo vitamin D level assessment at the beginning of treatment and receive supplementation if found deficient, while the control group will proceed without initial vitamin D evaluation.

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Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients diagnosed with Class I malocclusion
• • Presence of maxillary transverse deficiency
• • Adolescents aged between 15 and 18 years
• • No systemic diseases, cleft lip/palate, or speech disorders
• • No history of prior orthodontic treatment
• • Willingness to undergo serum vitamin D testing
• • Voluntary participation in the study with signed informed consent
• • Good oral hygiene status
• Exclusion Criteria:
• • Patients with systemic diseases
• • Patients who smoke
• • Patients with poor oral hygiene
• • Patients with cooperation or compliance issues
• • Patients with intellectual disabilities
• * Patients with unmonitored or insufficient pre-treatment vitamin D levels, including:
• • Those who had insufficient vitamin D levels before treatment, were started on supplementation by the endocrinology department, but still had insufficient levels at the T2 measurement
• • Those who were not tested before treatment but were found to have sufficient vitamin D levels only at T2