Oxalate and Citrate in Humans - Response to Citrate

Launched by UNIVERSITY OF CHICAGO · Apr 17, 2025

Keywords

ClinConnect Summary

This clinical trial, titled "Oxalate and Citrate in Humans - Response to Citrate," is designed to better understand how two substances found in food, oxalate and citrate, affect the body and the likelihood of developing kidney stones. The researchers will look at how the levels of oxalate and citrate in urine change after participants take a substance called potassium citrate. This study aims to gather information that could help reduce the risk of kidney stones in the future.

To participate in this study, individuals must be between 18 and 70 years old. There are two groups: those who have had at least one calcium-based kidney stone (called stone formers) and those who have never had a kidney stone (called non-stone formers). Participants who have certain types of kidney stones or specific health issues will not be eligible. The trial is not yet recruiting participants, but those who qualify can expect to provide urine samples and take potassium citrate for the duration of the study. This research is essential as it could provide valuable insights into preventing kidney stones and improving kidney health.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• * Stone formers (SF):
• • Age 18-70
• • History of at least one calcium-based kidney stone
• * Non-stone formers (NSF):
• • Age 18-70
• • No history of kidney stone
• • 24-hour urine oxalate within lab normal (\<50mg/day)
• Exclusion Criteria:
• • History of primarily uric acid, cysteine, or struvite stones
• • History of severe acid-base abnormality, very low (less than 100mg/day) or very high (greater than 1500mg/day) urine citrate
• • Any controls or SF participants who cannot stop diuretic medication or alkali supplementation for the course of the study period
• • Chronic kidney disease (glomerular filtration rate \<75 ml/min/1.73m2.
• • NSF and SF with extreme levels of urine citrate will be excluded from this small initial study to reduce heterogeneity and remove focus from the extremes of citrate levels.