Characterising the Loss of Haemostasis in Haemorrhagic Fever With Renal Syndrome

Launched by LIVERPOOL SCHOOL OF TROPICAL MEDICINE · Apr 23, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a disease called Haemorrhagic Fever With Renal Syndrome (HFRS), which is caused by viruses known as hantaviruses. HFRS can lead to serious issues like kidney failure and bleeding. The goal of this research is to understand why patients with HFRS have problems with blood clotting, how different types of hantaviruses affect the severity of the disease, and whether a scoring system developed in China can help predict how likely patients in Europe are to recover or face serious complications.

To participate in this study, you must be at least 18 years old and have a confirmed diagnosis of HFRS. Pregnant women can also join. During the trial, hospitalised patients will have their blood tested to look for specific markers and to understand how their blood clots in real-time. Researchers will compare patients who experience bleeding with those who do not to find patterns that might help doctors better assess risks and identify potential treatments for HFRS. Please note that the trial is not yet recruiting participants.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients aged 18 or older, including pregnant women
• • Laboratory-confirmed HFRS (serology and/or RT-PCR)
• • Willing and able to provide informed consent
• Exclusion Criteria:
• • Patients under 18 years of age
• • Co-infections with other pathogens
• • Pre-existing coagulation disorders
• • Use of anticoagulant medication
• • Inability or refusal to provide consent