The Study of Differences in Eosinophil Function and Subsets in Patients With Eosinophilic Pulmonary Diseases

Launched by PEKING UNION MEDICAL COLLEGE HOSPITAL · Apr 22, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how different types of eosinophils (a kind of white blood cell) function in patients with specific lung diseases that involve high levels of eosinophils. These conditions include eosinophilic granulomatosis with polyangiitis, idiopathic hypereosinophilic syndrome, and others. The goal is to identify the different subtypes of eosinophils in the blood and understand how these differences can affect treatment options for patients. By doing this, the researchers hope to improve the care and management of people with these eosinophilic pulmonary diseases.

To participate in this study, individuals must be between the ages of 18 and 75 and have a consistently high eosinophil count in their blood for at least six months, without any secondary reasons for this increase. Healthy volunteers who match the age and gender of the study participants are also invited to join. Participants can expect to have their blood tested to help identify eosinophil subtypes, and they will be asked to share information about their health. It's important to note that those with certain lung infections, cancers, or who cannot provide consent or cooperate during the study will not be eligible.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • For Healthy Volunteers: healthy volunteers matching the age and gender of the study subjects
• • For EPD: ① Persistent eosinophil count increase\>1500 per cubic millimeter for more than 6 months. ② Lack of evidence of a secondary cause of eosinophilia is required. ③ Signs and symptoms of end-organ damage presumed to be secondary to eosinophilia
• Exclusion Criteria:
• • Patients with concurrent definitive pulmonary infections, malignancies, or other parenchymal lung diseases;
• • Patients who are unable or unwilling to cooperate with the collection of clinical information (e.g., due to mental disorders, memory impairments, etc.);
• • Patients who are unable to provide informed consent.