Monitoring Nutritional Consequences of Obesity Treatment on Women's Health

Launched by WAGENINGEN UNIVERSITY AND RESEARCH · Apr 17, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how different treatments for obesity affect women's health over time. The focus is on how these treatments influence nutrition, muscle strength, and reproductive health, as well as how they might impact pregnancy outcomes and child development. If you are a woman aged 18 to 55 with obesity (a body mass index of 30 or more) and are currently receiving treatment like bariatric surgery or anti-obesity medication, you might be eligible to participate.

If you join the study, you will help researchers by completing questionnaires and providing samples of blood, urine, and stool. You will also undergo tests to measure body composition and muscle strength, which may take place over a period of up to 10 years. This research aims to better understand the long-term effects of obesity treatment on women's health, ultimately leading to improved care and support for women facing these challenges.

Gender

FEMALE

Eligibility criteria

• General Inclusion Criteria:
• • Female sex at birth
• • Aged 18-55 years of age
• • Living with obesity (BMI ≥ 30 kg/m2)
• * Approved for obesity treatment in one of the participating hospitals:
• • Undergoing primary bariatric surgery (RYGB, OAGB or SG)
• • Receiving obesity medication (any type) with a BMI ≥30 kg/m2 under medical supervision.
• • For those undergoing MRI, DEXA and quantitative ultrasound scan: Willing to be informed about incidental findings of pathology and approving of reporting this to their general physician.
• Additional inclusion criteria for birth cohort:
• • Being pregnant
• • Age 18-45 years of age
• • Having received prior obesity treatment, either surgical (RYGB, OAGB, SG) or pharmacological for at least 4 months under medical supervision (any type).
• General Exclusion Criteria:
• • Male sex at birth
• • Aged \<18 or \>55 years of age
• • BMI \<30 kg/m2
• • Not able to read and/or write in Dutch
• • Undergoing a revisional or secondary bariatric procedure (excluding previous gastric banding)
• • Malnutrition due to other chronic condition, specifically malignancy, substance abuse
• • (mental) condition that makes it impossible to fill out a questionnaire correctly.
• • For those undergoing a DEXA scan: height \>196 cm or weight \>160 kg
• • For those undergoing a MRI scan: having a contra-indication to MRI scanning including (but not limited to) pacemakers and defibrillators, intraorbital or intraocular metallic fragments, ferromagnetic implans or claustrophobia.
• Additional exclusion criteria birth cohort:
• • Aged \<18 or \>45 years of age
• • \>25 weeks of gestation
• • Multiple pregnancy
• • Reversal of the bariatric procedure