Wilson's Disease Treated With D-Penicillamine: Characterization of Skin Damage Secondary to Treatment by Measuring Skin Elasticity

Launched by CENTRE HOSPITALIER UNIVERSITAIRE DE SAINT ETIENNE · Apr 18, 2025

Keywords

ClinConnect Summary

This clinical trial is studying the effects of a medication called D-Penicillamine on patients with Wilson's disease, a genetic condition that causes harmful amounts of copper to build up in the body. While D-Penicillamine helps remove excess copper, it can also cause side effects, particularly affecting the skin. The researchers want to better understand how this treatment impacts skin elasticity, which is the skin's ability to stretch and bounce back. To do this, they will create a mold of the skin's surface from both Wilson's disease patients and healthy volunteers to compare the two.

To be eligible for this study, participants must be at least 12 years old and have a confirmed diagnosis of Wilson's disease, currently being treated with D-Penicillamine. Healthy volunteers who are also at least 12 years old, matched in age and gender with the patients, can join too. Participants will need to provide consent and meet certain health criteria. The study is not yet recruiting participants, but it aims to help improve treatment approaches for those affected by Wilson's disease by gaining insights into skin changes caused by the medication.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• Diseased patients :
• • Patient over 12 years old
• • Patient with Wilson's disease confirmed by genetic analysis
• • Patient followed up in the Wilson's Disease Reference Center for his care
• • Patient treated with D-Penicillamine
• • Patient with no other known elastic tissue pathology
• Healthy volunteers :
• • Patient over 12 years old
• • Patient followed up in the dermatology department of St Etienne University Hospital
• • Patient matched on sex and age with a patient from the "Wilson's disease" group
• • Patient with no elastic tissue pathology
• All patients :
• • Patient affiliated to a national social security
• • Patient with written informed consent
• Exclusion Criteria:
• All patients:
• • Patient not taking a treatment (at investigator's discretion) that may modify skin elasticity
• • Patient with pathological lesion(s) on forearm or cheek
• • Patient with a potentially active/rejuvenative forearm or cheek treatment
• • Patient having applied cream and/or make-up to the areas to be molded (forearm and cheek)
• • Patient under guardianship
• • Patient unable to follow study procedures
• • Pregnant or breast-feeding women