Research on Ultrasound Diagnostic Criteria for Intracranial and Extracranial Arterial Serial Stenosis

Launched by XUANWU HOSPITAL, BEIJING · Apr 20, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how ultrasound can help doctors evaluate the severity of blockages in certain brain arteries, specifically the middle cerebral artery and the V4 segment of the vertebral artery. The goal is to create clear guidelines for using ultrasound to assess these conditions, which can help doctors make better treatment decisions and identify patients at risk for strokes. The study will involve patients who are undergoing stenting procedures for severe blockages in their carotid or vertebral arteries.

To be eligible for this trial, participants need to be at least 18 years old and have been diagnosed with significant blockages in their arteries that require stenting. They will undergo several tests, including ultrasounds and imaging studies, and will be followed for one year to monitor their health and any potential stroke-related issues. Overall, this study aims to improve how we diagnose and treat patients with these serious vascular conditions.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patients diagnosed by carotid ultrasound with severe stenosis of the extracranial segment of the internal carotid artery or severe stenosis of the initial segment of the unilateral vertebral artery;
• • 2. Perform stent placement surgery within 2 weeks of ultrasound examination, and perform DSA and CTA examinations;
• • 3. Age ≥ 18 years old;
• • 4. Clinical data is complete.
• Exclusion Criteria:
• • 1. Bilateral temporal windows are not transparent to sound;
• • 2. Patients with severe stenosis of the extracranial segment of the internal carotid artery have ipsilateral MCA occlusion/ipsilateral common carotid artery severe stenosis or occlusion;
• • 3. Patients with severe stenosis of the extracranial segment of the internal carotid artery have severe stenosis of the contralateral carotid artery;
• • 4. Patients with severe stenosis or occlusion of the anterior circulation in the initial segment of unilateral vertebral artery;
• • 5. Severe stenosis or occlusion of bilateral subclavian arteries;
• • 6. Vasospasm caused by subarachnoid hemorrhage, etc;
• • 7. Related MCA or vertebral artery thrombolysis or endovascular treatment;
• • 8. Arrhythmias such as atrial fibrillation or heart failure that affect velocity measurement;
• • 9. CT, MRI, DSA examination contraindications or refusal of examination;
• • 10. Severe bleeding disorders or coagulation dysfunction;
• • 11. Merge serious diseases of other organs or tissues.