Enhanced Recovery After Surgery (ERAS) for Complicated Appendicitis

Launched by CEDARS-SINAI MEDICAL CENTER · Apr 22, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at a new approach to help patients recover faster after surgery for complicated appendicitis, which is a serious form of the condition. The goal is to see if patients can safely go home just three days after a laparoscopic appendectomy (a minimally invasive surgery to remove the appendix) while taking oral antibiotics. Researchers want to find out how well patients follow the recovery instructions and if this method leads to fewer complications or hospital readmissions.

To participate in the trial, patients must be between 18 and 65 years old and have been diagnosed with complicated appendicitis. They should be able to follow up with the study procedures after their surgery. Unfortunately, some individuals, like those with certain medical conditions or who are pregnant, won’t be eligible to join. If you take part, you can expect to be monitored closely during your recovery at home, helping to ensure your safety and comfort throughout the process.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Individuals between the ages of 18 and 65 years of age.
• • Patients undergoing a laparoscopic appendectomy.
• • Diagnosis of complicated appendicitis based on pre-operative imaging or intra-operative assessment. The definition of a complicated appendicitis will include: (a) perforated appendicitis, without generalized peritonitis; (b) gangrenous appendicitis, without generalized peritonitis; (c) suppurative appendicitis; (d) iatrogenic perforation of the appendix.
• • Meet criteria for discharge from the post-anesthesia care unit (PACU).
• • Ability to reliably follow up with the study procedures.
• Exclusion Criteria:
• • Age \< 18 years or \> 65 years.
• • Pregnancy.
• • Homelessness.
• • Patients who present with generalized peritonitis.
• • Patients with comorbid conditions, including diabetes mellitus, immunosuppressed state for any reason, patients on chronic anticoagulation (excluding Aspirin 81 mg).
• • Patients who present with septic shock.
• • Patients who require conversion to an open appendectomy.
• • Patients who present with additional findings on imaging studies or intra-operatively, including ileus or small bowel obstruction.
• • Based on surgeon's clinical judgment for reasons that may not be outlined above.
• • Allergy or intolerance to study medication(s)