Efficacy and Safety of BRIMOCHOL PF and CARBACHOL PF in Chinese Presbyopia Patients
Launched by ZHAOKE (GUANGZHOU) OPHTHALMOLOGY PHARMACEUTICAL LTD. · Apr 23, 2025
Trial Information
Current as of July 24, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is investigating two eye drops, BRIMOCHOL PF and CARBACHOL PF, to see how effective and safe they are for treating presbyopia, a common condition that affects the ability to see things up close, especially in people aged 45 to 75. The trial is taking place in multiple centers in China and involves participants who meet certain criteria, such as having a specific level of distance vision and difficulty seeing nearby objects. Participants need to have a corrected near vision score below a certain level to qualify.
If you or a family member are interested in participating, you would be involved in a study that requires visits to the clinic for screenings and follow-up assessments. The study is designed to ensure safety, so participants will need to meet specific health criteria and cannot have certain eye conditions or surgeries. This trial is currently recruiting, and it could be a good opportunity to help advance treatments for presbyopia while also receiving care and monitoring for your eyesight.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • 1. At Visit 1 (Screening Period), the age ranges from 45 to 75 years old, regardless of gender
- • 2. At Visit 1 (Screening Period), the corrected distance visual acuity of either eye is ≥ 0.8 (National Standard Logarithmic Visual Acuity Scale,decimal visual acuity) in the clinical routine manifest refraction (distance vision).
- • 3. At Visit 1 (Screening Period), the manifest refraction (distance vision under mesopic conditions) results are as follows: For any eye,-4.00D ≤ equivalent spherical lens power ≤ +2.00D, and the negative cylinder lens power is ≥-2.00D;
- 4. At least one eye meeting the following at both Visit 1 and Visit 2:
- • 1. Under mesopic conditions, monocular corrected near visual acuity (MCNVA) ≤65 ETDRS letters (equivalent to decimal visual acuity 0.4) ;
- • 2. Under mesopic conditions, monocular corrected near visual acuity with a multiple-pinhole occluder (MCNVA_P) improves by ≥15 ETDRS letters compared to monocular corrected near visual acuity without the occluder (MCNVA).
- • 5. During Visit 1 (Screening Period) and Visit 2, both eyes must meet the following criteria:under mesopic conditions, binocular corrected near visual acuity (BCNVA) is ≤65 ETDRS letters (equivalent to decimal visual acuity 0.4);
- • 6. Any eye is phakic or implanted with a monofocal intraocular lens (IOL);
- • 7. Normal iris and pupillary morphology in any eye, with normal light reflex and an interocular pupillary diameter difference ≤1 mm during screening;
- Exclusion Criteria:
- • 1. Use of corneal or scleral contact lenses within 28 days prior to screening or planned for the duration of the study;
- • 2. Narrow anterior chamber angle (Van Herick grade ≤2 via slit lamp examination) or previous iridotomy or resection in either eye;
- • 3. Ocular history in any eye: hyphema, ciliary body detachment, iridodonesis, or ocular trauma;
- • 4. Any eye with a corneal abnormality that, in the judgment of the investigator, affects visual acuity or intraocular pressure measurements, including moderate to severe dry eye (e.g., significant signs of ocular surface damage (≥5 corneal fluorescein staining spots) on slit lamp microscopy);
- • 5. Any phakic eye has a history of lens tremor, subluxation, or suspected zonular laxity; or any pseudophakic eye has undergone posterior capsulotomy or uses multifocal or extended depth of focus intraocular lenses.
- • 6. Any eye with an axial length of ≥26mm;
- • 7. Either eye has undergone intraocular or corneal surgery (only non-complicated cataract surgery with a monofocal lens placed in the capsular bag more than 6 months after the date of surgery is permitted; complicated cataract surgery is defined as surgery that has resulted in a rupture of the capsule or placement of an IOL outside the capsule (ciliary sulcus, scleral or iris fixation, anterior chamber, etc.));
- • 8. Either eye has a history of congenital or traumatic cataract, congenital aphakia, or opacities in the refractive media that affect visual acuity in the visual axis area.
- • 9. History of uveitis, low intraocular pressure (IOP \< 9 mmHg), glaucoma or hypertension (IOP \> 21 mmHg) or pseudoexfoliation syndrome in either eye;
- • 10. Active ocular or periocular infection or inflammation in either eye, or a history of recurrent infection or chronic infection (e.g., herpes virus infection) in either eye;
- • 11. Either eye has a history of retinal diseases (such as retinal detachment, age-related macular degeneration, diabetic retinopathy, peripheral retinal diseases that increase the risk of the subject as judged by the investigator) or optic nerve abnormalities.
- • 12. During the screening period, any eye has any ocular disease other than presbyopia that requires treatment with ocular preparations, intravitreal injection or ocular surgery during the study period (except artificial tears, which can be used on the day of ocular examination during the screening period and on non-treatment visits).
About Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd.
Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd. is a leading biopharmaceutical company dedicated to the research, development, and commercialization of innovative therapies for ocular diseases. With a strong focus on ophthalmic solutions, Zhaoke leverages cutting-edge science and technology to address unmet medical needs in the field of eye care. Committed to improving patient outcomes, the company conducts rigorous clinical trials and collaborates with global partners to enhance its product pipeline and ensure the highest standards of safety and efficacy in its offerings.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Wenzhou, Zhejiang, China
Patients applied
Trial Officials
Jia Qu
Principal Investigator
Optometry Hospital of Wenzhou Medical University
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported