Study of the Impact of HYPOglycaemia on Sarcopenia in CIRrhosis

Launched by CENTRE HOSPITALIER UNIVERSITAIRE DIJON · Apr 25, 2025

Keywords

ClinConnect Summary

This clinical trial is investigating the effects of low blood sugar (hypoglycemia) on muscle loss (sarcopenia) in patients with cirrhosis, a serious liver condition. Researchers want to understand how nighttime drops in blood sugar might worsen muscle and fat breakdown, leading to malnutrition. They believe that by monitoring blood sugar levels continuously, they can find a link between these low levels and muscle loss, which is common in cirrhosis patients and can lead to more health problems.

To participate in the study, you must be at least 18 years old and diagnosed with cirrhosis according to specific medical guidelines. You should also be regularly monitored by a healthcare provider for your cirrhosis. However, there are certain exclusions, such as having active cancer, recent severe complications from cirrhosis, or being pregnant. If you join the study, you can expect to have your blood sugar levels monitored closely and undergo tests to assess your muscle health. The findings could help improve how patients with cirrhosis are managed and treated, particularly regarding their nutrition and muscle strength.

Gender

ALL

Eligibility criteria

• Inclusion criteria:
• • Age ≥18 years
• • Person with oral consent
• • Patient with cirrhosis according to the 2021 EASL criteria (1)
• • Patient receiving regular six-monthly and systematic monitoring of cirrhosis, according to the European recommendations of the EASL (2), or French recommendations of the TNCD (3) and HAS (4), including a clinical examination, a biological work-up (to calculate the CHILD-PUGH score and monitor alpha-feto-protein), AND requiring imaging to screen for HCC of hepatocellular carcinoma using cross-sectional imaging (by MRI and/or hepatic CT scan).
• Exclusion Criteria:
• • Patients with active cancer or treated within the last 6 months
• • Patient with an acute episode of cirrhosis decompensation (ongoing antibiotic treatment for an active infection, gastrointestinal bleeding, hepatic encephalopathy, acute alcoholic hepatitis) less than one month old.
• • Treatment with systemic corticosteroids, in progress or within the last 3 months
• • Patient with organ transplant
• • Person not affiliated to or not benefiting from a social security scheme
• • Person under legal protection (curatorship, guardianship)
• • Person subject to a legal protection measure
• • Pregnant or breast-feeding women
• • An adult who is incapable or unable to give consent
• • Minors
• • Patients already included in an interventional study who may interfere with the evaluation of this study.