Impact of Protein Supplementation and Resistance Training on Body Composition, Functional Parameters, Metabolic Adaptation, and Nitrogen Balance in Adults Aged 45 Years and Older With Overweight or Obesity Receiving Incretin-based Medications

Launched by ASSUTA MEDICAL CENTER · Apr 27, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how protein supplements and resistance training can help adults aged 45 and older who are overweight or obese. Specifically, it aims to see how these two factors affect body composition (like muscle and fat), physical function, metabolism, and overall health in people who are also taking certain medications for weight management. The study will involve 240 participants who will be divided into two groups: one group will receive protein supplements and participate in weekly resistance training, while the other group will not receive any interventions. The study will last for six months, with evaluations at the start, three months, and six months.

To be eligible for this trial, participants must be at least 45 years old, have a body mass index (BMI) of 27 or higher, and be able to read and speak Hebrew. They also need to be starting treatment with specific weight-loss medications. Participants will be encouraged to follow a healthy diet and exercise plan throughout the study. It’s important to note that individuals with certain medical conditions or who have had specific weight-loss surgeries may not qualify for this trial. Overall, this study aims to find out if adding protein and exercise can improve health outcomes for older adults struggling with weight management.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adults aged ≥45 years.
• • Overweight or obese (BMI ≥30, or BMI ≥27 with at least one obesity-related comorbidity).
• • Eligible to receive incretin-based weight loss medications (e.g. Wegovy or Mounjaro).
• • Able to read and speak Hebrew fluently.
• Exclusion Criteria:
• • Medical contraindications for incretin-based weight-loss medications.
• • Current treatment with insulin or sulfonylurea medications.
• • Inflammatory bowel disease.
• • Active or unstable psychiatric disorders or cognitive impairment.
• • Active bulimia nervosa.
• • Previous bariatric surgery or bariatric endoscopic procedures.
• • Use of other weight management medications within the past month.
• • Weight loss of ≥5% within the past three months.
• • Implanted cardiac pacemaker or other electronic implants.
• • Regular resistance training within the past three months.
• • Regular use of protein supplements.
• • Allergy or intolerance to dairy proteins or vegan lifestyle.