Changes in Glucose Tolerance in Patients With Cirrhosis Peri-Liver Transplant

Launched by UNIVERSITY OF CHICAGO · Apr 22, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at how to predict the risk of developing diabetes in adults with cirrhosis who are preparing for a liver transplant. The researchers want to understand whether specific tests, such as blood tests, body measurements, and even devices that monitor glucose levels, can help identify which patients are more likely to face diabetes after their transplant.

To participate, you must be over 18 years old, have been diagnosed with cirrhosis, and be able to provide consent. If you join the study, you will wear a continuous glucose monitor and a wrist device that tracks your activity, and you will take a glucose tolerance test both before and after your transplant. This information can help doctors improve care for future liver transplant patients. Please note that some people, like those with certain medical devices or a history of diabetes diagnosed more than five years ago, may not be eligible to participate.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients presenting to liver transplant clinic with a diagnosis of cirrhosis.
• • Age \>18 yrs.
• • Ability to understand and sign written consent form, or have a legally-authorized representative or proxy who can be approached for consent
• Exclusion Criteria:
• • Patients without consent
• • Patients with implantable cardioverter defibrillator devices or automated implantable cardioverter defibrillator devices will be excluded from the bio-electrical impedance analysis portion of the measurements.
• • Patients with unremovable electrical medical devices or devices that cannot turn off will be excluded from the bio-electrical impedance analysis measurements
• • Pregnant patients
• • Incarcerated patients
• • Patients with a history of type 2 diabetes mellitus diagnosed \> 5 years ago will be excluded from the Oral Glucose Tolerance Test portion of the study