A Global, Integrated, Personalized, Stage-related, Multimodal Therapeutic Approach for Rectal Adenocarcinoma Based on Organ Sparing and Mininvasivity

Launched by FONDAZIONE DEL PIEMONTE PER L'ONCOLOGIA · Apr 29, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a new approach to treating rectal adenocarcinoma, a type of cancer in the rectum that has not spread to other parts of the body. The goal is to find personalized treatment plans based on the stage of cancer, with a strong emphasis on preserving the rectum and using less invasive methods whenever possible. This means that, if a patient’s cancer is at an early stage, doctors will try to treat it without removing the rectum. If that’s not possible, they will use techniques that are less invasive, like laparoscopic (small incision) or robotic surgeries, to help reduce the impact of treatment on the patient’s body and quality of life.

To be eligible for this trial, participants need to be 18 years or older and able to give informed consent. They should have specific types of rectal adenocarcinoma, such as those with high-risk features or those who have responded well to previous treatments. If you decide to participate, you will receive a tailored treatment plan based on your cancer stage, and you can expect close monitoring and support throughout the process. This trial is currently recruiting participants of all genders, and it focuses on helping patients maintain their quality of life while effectively treating their cancer.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients aged ≥18 yrs old
• • Patients able to sign the informed consent
• • Patients with High Risk pT1 rectal adenocarcinoma endoscopically excised
• • Patients with cT2-3aN0 rectal adenocarcinoma who has complete/major response to EXPERIMENTAL CRT
• • Patients with cT3b4N0-1 rectal adenocarcinoma who has complete/major response to STANDARD CRT
• Exclusion Criteria:
• • cT2-4 any NM0 who don't reach cCR or cMR after experimental/standard CRT
• • Pregnancy