Comparison of Phaco Surgery With Goniosynechialysis Versus Trabeculectomy in Glaucoma Treatment

Launched by UNIVERSITY OF MEDICINE AND PHARMACY AT HO CHI MINH CITY · Apr 23, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at two different surgical methods for treating primary angle-closure glaucoma, a condition that can increase eye pressure and lead to vision loss. The researchers want to find out if a combined procedure called phacoemulsification with goniosynechialysis (Phaco-GSL) is as effective and safe as trabeculectomy, which is a more traditional surgery. They will compare how well each procedure controls eye pressure, any complications that may arise after surgery, and how quickly patients recover their vision.

To participate in the trial, you need to be at least 40 years old and have certain eye conditions, including high eye pressure despite using medications. You will be randomly assigned to one of the two surgical methods and will need to attend follow-up appointments at set times over the next two years to check your eye health and pressure. The trial has not started recruiting participants yet, but if you're interested, it’s a chance to contribute to important research that could help many others with glaucoma.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥ 40 years
• • Peripheral anterior synechiae (PAS) \>180°
• • Glaucomatous optic neuropathy with visual field loss
• • Intraocular pressure (IOP) \> 21 mmHg despite medication
• • Ability to consent and comply with follow-up
• • Cataract grade 1 to 3 according to LOCS III
• • Best corrected visual acuity (BCVA) ≥ 0.3 logMAR (equivalent to 20/40 Snellen or worse)
• Exclusion Criteria:
• • Very advanced glaucoma (only light perception vision)
• • Secondary angle-closure etiologies
• • Prior ocular surgeries or laser peripheral iridotomy (PI)
• • Allergy to 5-fluorouracil (5-FU), if used postoperatively
• • Irreversible corneal disease
• • Chronic corticosteroid use
• • Poor follow-up compliance
• • Cataract grade 4 or 5 (LOCS III)
• • Phacomorphic, phacolytic, or subluxated cataracts