The Impact Of Respiratory Neuromuscular Stimulation On Patients With Invasive Mechanical Ventilation

Launched by CAPITAL MEDICAL UNIVERSITY · Apr 28, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at how a treatment called Respiratory Neuromuscular Electrical Stimulation (NMES) can help patients who are on invasive mechanical ventilation, which is often needed for critically ill patients in the intensive care unit. Mechanical ventilation can help save lives, but it can also lead to problems with the diaphragm, the main muscle used for breathing. The trial aims to find out if using electrical stimulation on both the diaphragm and abdominal muscles can improve breathing and overall health for these patients.

To participate in this trial, individuals need to be between 18 and 80 years old and have been on mechanical ventilation for more than 48 hours while being stable in terms of their vital signs. They also need to have a specific score that indicates their level of sedation. However, some people won't be eligible, such as those with pacemakers, recent surgeries, or certain medical conditions. Participants can expect to receive this stimulation treatment as part of the study and help researchers understand how it can improve respiratory function and recovery for critically ill patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Aged between 18 and 80 years;
• • 2. Mechanical ventilation duration \> 48 hours;
• • 3. Hemodynamically stable;
• • 4. RASS score ranging from 1 to -2.
• Exclusion Criteria:
• • 1. Having a pacemaker implanted;
• • 2. Unhealed surgical wounds in the chest or abdomen;
• • 3. Pregnant women and lactating women;
• • 4. History of recent airway surgery or trauma;
• • 5. Surgery in the neck, chest, or upper abdomen;
• • 6. Intracranial hypertension;
• • 7. Contraindications for esophageal pressure catheter placement;
• • 8. Withdrawal of life support.