Aspirin 150 mg vs 100 mg for Prevention of Preeclampsia in High-Risk Obese Pregnant Women

Launched by FANG HE · Apr 23, 2025

Keywords

ClinConnect Summary

This clinical trial is studying the effects of two different doses of aspirin—150 mg and 100 mg—on preventing preeclampsia in high-risk obese pregnant women. Preeclampsia is a serious condition that can develop during pregnancy, characterized by high blood pressure and possible damage to other organs. Obese women are at a higher risk for this condition, making it important to find effective prevention strategies. The trial aims to determine which dose of aspirin is more effective and safe for preventing preeclampsia in these women.

To be eligible for this trial, participants need to be between 18 and 45 years old, be 12 to 16 weeks pregnant with a single baby, and have a body mass index (BMI) of 35 or higher, or a BMI between 28 and 35 with additional risk factors like a history of preeclampsia or chronic high blood pressure. Participants will be randomly assigned to receive either 100 mg or 150 mg of aspirin daily from week 12 to week 16 of their pregnancy. They will be monitored throughout the study to assess the effects of the treatment. This trial is not yet recruiting, but it aims to provide valuable information on the best dose of aspirin for preventing preeclampsia in obese pregnant women.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • 1. Age 18-45 years;
• • 2. Pregnancy 12-16 weeks, NT normal;
• • 3. Singleton pregnancy;
• • 4. a.BMI ≥35kg/m²; b. 28≤BMI \<35 kg/m², and at least one risk factor: history of preeclampsia, chronic hypertension, type 1 or type 2 diabetes, autoimmune disease (excluding antiphospholipid syndrome), nulliparous, family history of preeclampsia, placental abruption, stillbirth, SGA, more than 10 years between pregnancies, in vitro fertilization-embryo transfer;
• • 5. Sign informed consent
• Exclusion Criteria:
• • 1. Aspirin allergy or contraindication (such as active gastric ulcer, coagulation disorder); 2. Multiple pregnancies; 3. Other severe comorbidities that may lead to pregnancy complications; 4. Seizures; 5. Renal disease, baseline proteinuria (proteinuria\> 3+, or protein-to-creatinine ratio ≥ 0.3); 6. Patients taking aspirin for other reasons (such as stroke, heart disease)