Investigating Periprosthetic Fracture Cultures in Arthroplasty

Launched by UNIVERSITY OF CHICAGO · Apr 23, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how to better diagnose infections in patients who have broken bones around joint replacements, specifically in the hip or knee. When a patient has a fracture near their prosthetic joint, it can be tough for doctors to know if an infection is present due to a lack of clear guidelines. By looking at lab tests and certain factors that might indicate an infection, the researchers hope to develop improved methods for diagnosing and treating these patients.

To participate in this study, you need to be an adult over 18 years old who has a fracture around a hip or knee joint replacement that requires surgery. This could involve either fixing the fracture or possibly replacing the joint again. Unfortunately, if you are receiving non-surgical treatment for your fracture or have a history of joint infections, you won't be eligible. The trial is set to take place at the University of Chicago Medical Center over a two-year period, starting in October 2025. If you qualify and choose to participate, you can expect to help contribute valuable information that could lead to better care for future patients in similar situations.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult patients (\>18 years old) with periprosthetic fractures around primary or revision hip or knee arthroplasty
• • Patients requiring operative management for these fractures (fixation or revision arthroplasty)
• • Patients presenting to the University of Chicago Medical Center during two (2) year period (October 2025 to October 2027)
• Exclusion Criteria:
• • Patients undergoing non-operative management for periprosthetic fractures
• • Any documented or reported history of past prosthetic joint infection of the involved joint
• • Sinus tract at the time of presentation at the involved joint