Prediabetes and Type 2 Diabetes in Aging

Launched by UŞAK UNIVERSITY · Apr 29, 2025

Keywords

ClinConnect Summary

This study will look at how prediabetes and type 2 diabetes in older adults relate to thinking skills, sense of direction, reaction time, physical function, and fatigue. It compares four groups: healthy older adults with normal blood sugar, those with prediabetes, those with type 2 diabetes that is fairly well controlled, and those with type 2 diabetes that is less well controlled. They will assess cognitive status using a brief thinking test (MoCA), along with several other tests of memory, coordination, and fatigue.

About 80 people aged 60 and older will take part at four clinics in Uşak, Turkey. At enrollment, participants will undergo a series of tests and blood tests, including a cognitive screening (MoCA), sense-of-direction questionnaire, reaction time test, blood sugar, morning cortisol, dual-task walking tests, a short walking test, fatigue questionnaires, and blood work (hemoglobin, ferritin, TSH, CRP). This is an observational study, meaning no treatment is given by the study, and personal data won’t be shared publicly. The study is led by Uşak University (principal investigator Kevser Gürsan).

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • for people without diabetes (healthy), those with Hemoglobin A1c Levels (HbA1c) normal range between 4% and 5.6%,
• • those with HbA1c level between 5.7% and 6.4%, those with prediabetes (Impaired Glucose Tolerance),
• • those with 6.5% -7.5% level and
• • those with HbA1c level above 7.5
• • criteria are being 60 years of age and older,
• Exclusion Criteria:
• • those who have major depression,
• • uncontrolled thyroid disease,
• • those with vitamin B12, folic acid deficiency and anemia,
• • those with uncontrolled hypertension,
• • those with nephropathy and retrophy,
• • those with any neuropsychological disorder, a history of alcohol, substance or drug addiction,
• • those using any neurological or psychological medication (anticonvulsant drugs, antidepressants, anxiolytics, etc.),
• • those with Alzheimer's and Parkinson's disease,
• • those with cancer,
• • those with lung disease