Urinary Proteomics to Guide Early Intervention to Prevent Complications in Type 2 Diabetes - a Feasibility Study
Launched by STENO DIABETES CENTER COPENHAGEN · Apr 23, 2025
Trial Information
Current as of July 04, 2025
Not yet recruiting
Keywords
ClinConnect Summary
This clinical trial is exploring a new method to help manage Type 2 diabetes and prevent serious complications like kidney and heart issues. Researchers want to see if testing urine for specific protein patterns can help identify patients at risk for these complications. By doing this, they hope to determine which patients would benefit from additional protective treatments.
To participate in the study, you need to be at least 18 years old and have Type 2 diabetes without severe heart failure symptoms. However, there are several conditions that would exclude someone from joining, such as severe kidney problems or recent heart issues. If eligible, participants will undergo tests and possibly receive new treatment options aimed at reducing the risk of complications. It’s important to note that the trial is not yet recruiting participants, so there will be more information available once it begins.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • 1. Men and women over 18 years of age.
- • 2. Type 2 diabetes with no clinical signs of HF NYHA Class IV
- • 3. Able to understand the written participant information and give informed consent.
- Exclusion Criteria:
- • 1. Heart failure NYHA class IV at screening
- • 2. Moderately - or severely increased albuminuria with a UACR ≥ 200 mg/g or CKD with an eGFR \< 30 ml/min/1.73m2 at the screening visit.
- • 3. A female who is pregnant, breastfeeding, or intends to become pregnant, or women of childbearing potential (WOCBP) who are not using highly effective contraceptive methods.
- • 4. Receiving therapy with all three of the study medication prior to enrolment.
- • 5. Myocardial infarction, unstable angina, stroke, or transient ischemic attack within 12 weeks prior to enrolment
- • 6. Known or suspected hypersensitivity to the study medications or related products
- • 7. History of pancreatitis at the screening visit
- • 8. Body mass index \< 18.5 kg/m2 at the screening visit
- • 9. Type 1 diabetes
- • 10. Serum potassium \> 5.0 mmol/L at the screening visit
- • 11. Addison's Disease
- • 12. Concomitant treatment with strong CYP3A4 inhibitors (e.g., itraconazole, ketoconazole, ritonavir, nelfinavir, cobicistat, clarithromycin, telithromycin, nefazodone)
- • 13. Treatment with a potassium-sparing diuretic (amiloride, triamterene)
- • 14. Treatment with other mineralocorticoid receptor antagonist than finerenone (e.g., spironolactone, eplerenone, esaxerenone, canrenone)
- • 15. Elevated Alanine Aminotransferase (ALT) \> 3x upper normal limit, autoimmune hepatitis, and/or severe hepatic impairment (including but not limited to a history of hepatic encephalopathy, a history of oesophageal varices or a history of portocaval shunt.)
- • 16. Autosomal dominant or autosomal recessive polycystic kidney disease
- • 17. Lupus nephritis or ANCA-associated vasculitis, or any other primary or secondary kidney disease requiring immunosuppressive therapy within 6 months prior to screening
- • 18. Kidney transplant or dialysis
- • 19. Presence or history of malignant neoplasms (except basal cell skin cancer or squamous cell skin cancer) within five years before screening.
- • 20. Any other history, condition, therapy, or uncontrolled intercurrent illness that could, as judged by the investigator, affect participant safety or compliance with study requirements.
- • 21. Known or suspected abuse of narcotics.
- • 22. Participant in another intervention study,
- • 23. Vulnerable (i.e., under guardianship) or mentally incapacitated subjects (i.e., not able to understand and sign the informed consent)
About Steno Diabetes Center Copenhagen
Steno Diabetes Center Copenhagen is a leading clinical research facility dedicated to advancing the understanding and treatment of diabetes and its complications. As a prominent sponsor of clinical trials, the center focuses on innovative research that bridges clinical practice and scientific inquiry, fostering collaborations with healthcare professionals, researchers, and patients. Committed to improving patient outcomes, Steno Diabetes Center Copenhagen emphasizes evidence-based approaches and cutting-edge methodologies to enhance diabetes management and care, ultimately contributing to the global fight against this chronic disease.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Herlev, , Denmark
Herlev, Hajdú Bihar, Denmark
Patients applied
Trial Officials
Peter Rossing, Clinical Professor
Principal Investigator
Steno Diabetes Center Copenhagen
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported