Mechanisms And Prognosis of Stroke-Heart Syndrome

Launched by CHENSHENG PAN · Apr 23, 2025

Keywords

ClinConnect Summary

This clinical trial, titled "Mechanisms and Prognosis of Stroke-Heart Syndrome," is studying how a condition called stroke-heart syndrome affects patients after they have a stroke. Stroke-heart syndrome can lead to serious heart problems and is linked to higher risks of death and poor recovery in stroke patients. The researchers want to understand how this syndrome develops and how it impacts a patient's ability to function, think, and cope emotionally after a stroke. By examining blood samples and brain scans, they hope to find new markers in the blood that could help identify patients at risk and develop better treatments in the future.

To be eligible for this trial, participants need to be admitted to the hospital within 48 hours of having a stroke, which can be either a blockage in the blood flow to the brain (ischemic stroke) or bleeding in the brain (hemorrhagic stroke). They should have moderate to severe stroke symptoms, measured by a specific scoring system. However, individuals with certain conditions, like previous brain injuries or severe heart diseases, cannot participate. If you join this study, you can expect to undergo tests and assessments that will help researchers learn more about the relationship between strokes and heart health, potentially leading to improved care for future patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patients admitted within 48 hours of onset, confirmed by CT/MRI as having a stroke (including acute ischemic stroke and hemorrhagic stroke).
• • 2. Moderate-to-severe stroke with NIHSS ≥ 5.
• Exclusion Criteria:
• • 1. Previous focal brain injury (such as stroke, brain surgery, traumatic brain injury, etc.).
• • 2. Brain dysfunction caused by other major neurological disorders than stroke (such as brain tumors, epilepsy, Parkinson's disease, etc.).
• • 3. Transient ischemic attack (TIA) and subarachnoid hemorrhage (SAH).
• • 4. History of cardiac diseases (such as coronary heart disease, heart failure, severe arrhythmias, congenital heart disease, cardiac surgery, valvular heart disease, or undiagnosed significant cardiac symptoms).
• • 5. Concomitant systemic diseases such as renal failure (eGFR \< 30), autoimmune disorders, severe infections, etc.
• • 6. History of dementia, depression, or other psychiatric disorders.
• • 7. Poor compliance and inability to cooperate with follow-up.