Restricted Versus Liberal Fluid Intake for Prevention of Bronchopulmonary Dysplasia

Launched by UNIVERSITY CHILDREN'S HOSPITAL BASEL · Apr 23, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at how different amounts of fluid intake might affect the health of premature infants, specifically those born before 30 weeks of pregnancy. Researchers want to find out if giving less fluid (about 135 mL per kilogram of body weight per day) compared to more fluid (about 165 mL per kilogram) can help reduce the risk of bronchopulmonary dysplasia (BPD), a serious lung condition, by the time these babies reach 36 weeks of development or if they pass away before that time.

To participate in this study, infants need to be hospitalized and born before 30 weeks of gestation. However, babies with certain health issues, such as serious heart problems or conditions that might affect their lung function or development, won't be eligible. If families choose to participate, they will be part of a study to see how these different fluid amounts impact their baby's health over time. The trial is not yet recruiting participants, but it aims to provide important insights into caring for very premature babies.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Hospitalised preterm infants born before 30 weeks 0 days gestation
• • Signed informed consent for further research use of health-related data
• Exclusion Criteria:
• • congenital malformations
• • diseases likely to affect life expectancy, lung function, fluid strategy, or neurodevelopment
• • renal disease requiring fluid management outside the clinical standard of care
• • congenital heart disease not including patent ductus arteriosus (PDA)