Effect of Systemic and Local Ozone Therapy in Lipedema

Launched by ANKARA ETLIK CITY HOSPITAL · Apr 30, 2025

Keywords

ClinConnect Summary

This clinical trial is studying the effects of ozone therapy on women diagnosed with lipedema, a condition that causes painful swelling in the legs and arms due to enlarged fatty tissue. The researchers want to see if ozone therapy—both applied directly to the skin and given through the body—can help reduce pain and improve the thickness of the affected tissue. This is important because pain is a significant issue for women with lipedema, impacting their daily activities and quality of life.

To participate in this study, women between the ages of 18 and 65 who have been diagnosed with lipedema and report a pain level of 5 or higher on a scale from 0 to 10 may be eligible. However, individuals with certain conditions, such as those causing swelling unrelated to lipedema or those taking specific pain medications recently, cannot join. Participants can expect to receive ozone therapy and will be monitored for changes in pain and tissue thickness throughout the study. This trial is currently active but not recruiting new participants at this time.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • To have been diagnosed with clinical lipedema.
• • Pain assessed by VAS of 5 or more
• • Being a woman
• • Being between 18-65 years old
• Exclusion Criteria:
• • Presence of venous insufficiency leading to subcutaneous changes
• • Having diseases that may cause edema
• • Use of painkillers (NSAIDs/Opioids) up to 1 week before the injection
• • Open wound or infection at the site of infection
• • Bleeding disorders or use of anticoagulant, antiplatelet drugs uncontrolled systemic disease
• • G6PD deficiency
• • Cases where the pain cannot be explained by lipoedematous tissue