Lactate and Glycerol Contribution to Gluconeogenesis

Launched by RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY · Apr 24, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how two substances in the body—glycerol, which comes from fat, and lactate, found in the blood—contribute to the production of glucose, especially in people with type 2 diabetes (T2D). The liver makes glucose from different sources, and this process can lead to high blood sugar levels, which is a concern for those with T2D. Researchers want to better understand the roles of glycerol and lactate in this process, especially when the body is fasting. They will also look at how a hormone called glucagon, which raises blood sugar, affects this conversion. This research could help find new ways to treat high blood sugar more effectively.

To participate in the trial, individuals aged 18 to 65 who are generally healthy may be eligible. This includes those who have obesity but do not have diabetes, as well as those with obesity and T2D. Participants will undergo three separate tests where they will receive special infusions and have their blood drawn multiple times for analysis. It’s important to note that people with certain medical conditions or those taking specific medications may not qualify for this study. The trial is currently not recruiting, but it aims to help improve treatments for managing blood sugar levels in the future.

Gender

ALL

Eligibility criteria

• • Inclusion Criteria for All Subjects
• • 1. Age 18-65 years.
• • 2. The subject is otherwise in good health, based on medical history and physical examination.
• • Inclusion Criteria for Lean Healthy Subjects without T2D
• • 1. No evidence of T2D or prediabetes as indicated by the American Diabetes Association (ADA), i.e., HbA1c \< 5.7%, fasting glucose \< 100 mg/dL, or use of glucose-lowering medications.
• • 2. Body mass index (BMI) \< 25.0 kg/m2.
• • Inclusion Criteria for Subjects with Obesity
• • 1. No evidence of T2D or prediabetes as per ADA criteria.
• • 2. 30.0 ≤ BMI ≤ 45.0 kg/m2.
• • Inclusion Criteria for Subjects with Obesity and T2D
• • 1. Evidence of T2D as indicated by ADA criteria.
• • 2. 30.0 ≤ BMI ≤ 45.0 kg/m2.
• • Exclusion Criteria for All Subjects
• • 1. Chronic medical conditions that may affect glucose metabolism, including active malignancy, tobacco use, HIV infection, kidney failure, liver dysfunction, alcoholism, pancreatitis, active viral/bacterial infection, current pregnancy/lactation, anemia, and severe cardiac or respiratory failure.
• • 2. Current medical therapy that affects glucose metabolism, such as glucocorticoids or oral contraceptive pills.
• • 3. Type 1 diabetes mellitus diagnosis and/or history of diabetic ketoacidosis.