A Study on the Peripheral Blood in Patients With Acute Coronary Syndrome

Launched by SECOND AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIVERSITY · Apr 24, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at the blood of patients with Acute Coronary Syndrome (ACS), a serious heart condition that can cause chest pain or heart attacks. The researchers want to understand how certain factors in the blood change after someone has ACS. They will focus on growth factors, inflammatory substances, and other proteins and metabolites to see how these changes might relate to the patient's recovery and overall health. To do this, they will collect blood samples from participants who have been admitted to the hospital for ACS and compare their results with a control group of patients who do not have any heart-related issues.

To be eligible for the study, participants must be adults aged 65 or older and have specific signs of ACS, which could include certain lab test results or symptoms like chest pain. Those in the control group should be healthy individuals without any heart problems. Participants can expect to have their blood drawn within 24 hours of being admitted to the hospital. This study is currently recruiting, and it is important to note that pregnant or breastfeeding women and people with certain serious health issues will not be included in the trial.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • For ACS group STEMI
• • cTn\>99th ULN or CK-MB\>99th ULN
• • ST-segment elevation with a convex upward morphology
• • in conjunction with one or more of the following conditions: persistent ischemic chest pain; echocardiographic evidence of abnormal segmental ventricular wall motion; or abnormal coronary angiography findings.
• • NSTEMI
• • cTn\>99th ULN or CK-MB\>99th ULN
• • accompanied by one or more of the following situations: persistent ischemic chest pain; new ST-segment depression or low and inverted T waves; echocardiography showing segmental ventricular wall motion abnormalities; abnormal coronary angiography.
• • UA
• • cTn normal
• • ischemic chest pain with an electrocardiogram showing transient ST-segment depression or flattened and inverted T waves
• • evidence of coronary artery stenosis (e.g., CTA demonstrating ≥ 50% stenosis) For CCS group
• • Clinical Diagnosis Consistent with CCS Categories, meet any one of the following clinical scenarios: Stable Angina Pectoris, Ischemic Cardiomyopathy, Post-ACS Stable Phase, Long-Term CAD Management, Vasospastic or Microvascular Disease, Asymptomatic CAD
• • Laboratory and Imaging Confirmation: Resting ECG without ST-segment elevation or dynamic changes (excluding ACS), cTn normal or stable (no acute myocardial injury), ≥50% luminal stenosis in ≥1 epicardial coronary artery For control group
• • Patients without coronary artery stenosis, valvular heart disease, structural heart disease, or any other kind of cardiomyopathy
• Exclusion Criteria:
• • Lactating or pregnant women
• • Patients with malignant neoplasms
• • Severe hepatic/renal dysfunction
• • Severe hematological disorders
• • Autoimmune diseases