Firmonertinib Versus Platinum Based Chemotherapy as First-line Treatment for NSCLC With EGFR PACC or EGFR l861q Mutation

Launched by ALLIST PHARMACEUTICALS, INC. · Apr 24, 2025

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ClinConnect Summary

This clinical trial is studying a new treatment called firmonertinib mesylate for patients with advanced non-small cell lung cancer (NSCLC) who have specific genetic mutations (EGFR PaCC or EGFR L861Q). The goal is to see if this new drug is more effective and safer than standard chemotherapy, which includes platinum-based medications. About 300 eligible patients will be randomly assigned to receive either firmonertinib (taken as a daily pill on an empty stomach) or a combination of chemotherapy drugs.

To participate, patients must be at least 18 years old, have not received previous systemic treatment for their NSCLC, and have a confirmed diagnosis with specific measurable tumors. They should also meet certain health criteria, such as having good overall health and sufficient organ function. Participants will need to provide samples of their tumor tissue and blood for testing. Throughout the trial, they will be monitored closely for any side effects and overall health outcomes. This study is currently recruiting participants, and it's an important step in finding potentially better treatments for this type of lung cancer.

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ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Voluntarily sign the informed consent form (ICF).
• • 2. Age ≥18 years at the time of ICF signing.
• 3. At least one measurable lesion per RECIST v1.1, meeting the following:
• • No prior local therapy (e.g., radiotherapy)
• • Not used for biopsy during screening
• 4. Histologically/cytologically confirmed non-squamous NSCLC, classified as:
• • Locally advanced (Stage IIIB/IIIC, unsuitable for curative surgery and/or definitive chemoradiotherapy)
• • Metastatic (Stage IV) (Based on UICC/AJCC 8th edition TNM staging)
• 5. Agreement to provide:
• • Recent tumor tissue (from untreated lesions)
• • Blood samples
• • Central lab-confirmed EGFR PACC or L861Q mutation (If tumor tissue is unavailable due to inaccessible lesions, sponsor consultation is required.)
• • 6. No prior systemic therapy for advanced/metastatic NSCLC.
• • Allowed if: Prior (neo)adjuvant/definitive chemoradiotherapy completed ≥12 months before recurrence/progression
• • 7. ECOG performance status 0-1.
• • 8. Life expectancy ≥12 weeks.
• • 9. Adequate bone marrow/organ function within 14 days before treatment (no transfusion/G-CSF within 2 weeks prior).
• 10. Women of childbearing potential (WOCBP):
• • Abstinence or contraception use
• • No egg donation
• 11. Non-sterilized males:
• • Abstinence or contraception use
• • No sperm donation
• • 12. CNS metastases allowed if protocol-specified criteria are met.
• Exclusion Criteria:
• • 1. Histologically/cytologically confirmed tumor with \>10% neuroendocrine carcinoma, sarcomatoid carcinoma, or squamous cell components.
• • 2. Known ALK-positive, ROS1-positive, RET fusion-positive, NTRK fusion-positive, BRAF V600E mutation, MET exon 14 skipping mutation, or other targetable alterations with approved therapies.
• 3. Prior treatments including:
• • 1. Systemic anti-tumor therapy for advanced/metastatic NSCLC (e.g., chemotherapy/targeted/immunotherapy). Neoadjuvant/adjuvant therapy exceptions per Inclusion Criterion #6.
• • 2. \>30 Gy thoracic radiotherapy within 6 months or non-thoracic radiotherapy within 4 weeks prior to first dose (brain radiotherapy exceptions per Inclusion Criterion #12).
• • 3. Any prior EGFR-targeted therapy (including investigational EGFR-TKIs, mAbs, bispecific antibodies, etc.).
• • 4. Strong CYP3A4 inhibitors within 7 days or inducers within 21 days prior to first dose.
• • 5. Anticancer traditional Chinese medicines within 2 weeks prior to first dose.
• • 6. Non-specific immunomodulators (e.g., interferon, IL-2, thymosin) within 2 weeks prior to first dose.
• • 7. Major trauma/surgery within 4 weeks prior to treatment initiation.
• 4. Clinically significant gastrointestinal abnormalities, including:
• • Moderate/severe atrophic gastritis
• • GI obstruction/perforation
• • Chronic diarrhea/short bowel syndrome
• • Major upper GI surgery (e.g., gastrectomy)
• • Inflammatory bowel disease (Crohn's/ulcerative colitis) or active intestinal inflammation
• • Inability to swallow tablets
• • 5. Uncontrolled systemic diseases.
• • 6. Severe acute/chronic infections.
• 7. Interstitial lung disease (ILD)/non-infectious pneumonia:
• • History requiring clinical intervention
• • Current presence
• • Suspicious imaging findings unresolved at screening
• • 8. Clinically significant cardiovascular dysfunction (active or history).
• • 9. Tumor invasion of critical adjacent structures (heart/esophagus/SVC etc.) with high bleeding/fistula risk. Exceptions may be considered if investigator assesses minimal risk.
• 10. Pulmonary comorbidities causing severe impairment, including:
• • 1. Baseline lung diseases (e.g., pulmonary embolism \[≤3 months\], severe asthma/COPD/restrictive disease)
• • 2. Autoimmune/connective tissue disorders with pulmonary involvement (e.g., rheumatoid arthritis, sarcoidosis)
• • 11. Residual toxicity \>Grade 1 (per NCI CTCAE v5.0) from prior anticancer therapy (except alopecia/neuropathy).
• 12. Concurrent malignancies except:
• • Cured localized skin cancers (BCC/SCC), superficial bladder cancer, cervical/breast DCIS, or papillary thyroid cancer
• • Other malignancies cured by radical therapy ≥3 years prior
• • 13. Pregnancy/lactation or planned pregnancy within 6 months post-treatment.
• • 14. Inability to comply with study procedures/follow-up.
• • 15. Known hypersensitivity to furmonertinib or excipients.
• • 16. History of allergic reactions to pemetrexed/cisplatin/carboplatin.
• 17. Other exclusionary per investigator judgment, including:
• • Alcohol/drug abuse
• • Severe comorbidities (including psychiatric) requiring treatment
• • Critical laboratory abnormalities
• • Social/familial factors compromising safety/data collection