Evaluating the Impact of Various Dietary Nitrate Supplements on Oral Health

Launched by SHATHA ALHULAEFI · Apr 24, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how different dietary nitrate supplements, specifically beetroot juice and freeze-dried beetroot crystals, might affect oral health. Researchers want to find out if these supplements can change important markers in saliva, like the acidity level and the types of bacteria present in the mouth. They will also look into how easy and acceptable it is for people to add these supplements to their daily diets.

To participate, you need to be a healthy adult between the ages of 18 and 65. Unfortunately, if you smoke, drink more than 14 units of alcohol a week, or have certain health conditions, you may not be eligible. If you join the study, you will be randomly placed into one of three groups: one will receive a placebo (a supplement without any active ingredients), another will take beetroot juice with a specific amount of nitrate, and the last group will take beetroot crystals with the same amount of nitrate. The study will last for four weeks, and you'll provide saliva samples and answer questionnaires at the start and end of the trial to help the researchers gather information about any changes in your oral health.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Healthy volunteers
• • Aged 18 - 65 years.
• Exclusion Criteria:
• • Aged less than 18 or more than 65 years old.
• • Current smoking
• • Alcohol consumption of greater than14 units per week.
• • Diagnosis of a chronic disease (e.g., cardiovascular disease, diabetes, cancer, or gastrointestinal disorders), including oral diseases.
• • Use of antibiotics within the past three months or medications/nutritional supplements that may affect the oral cavity (e.g., prebiotics, probiotics, or hormone replacement therapy).
• • Regular use of antibacterial mouthwash or xylitol-containing products (e.g., gum or toothpaste) or the use of proton pump inhibitors.
• • Presence of braces/invisalign or dentures.
• • Known allergy to any food, including beets
• • Adherence to dietary restrictions (e.g., weight loss diet)
• • Eating disorders that may limit participation in the study.
• • Currently pregnant, breastfeeding or trying to become pregnant.
• • Participation in other studies.