Analysis of Risk Factors for Hearing Loss in Survivors of Cancer Occurred During Childhood, Adolescence or Young Adulthood

Launched by GUSTAVE ROUSSY, CANCER CAMPUS, GRAND PARIS · Apr 25, 2025

Keywords

ClinConnect Summary

This clinical trial is studying the risk of hearing loss in individuals who were treated for cancer before the age of 25. The researchers want to understand how certain factors might contribute to hearing impairment in these patients, who are now between 18 and 50 years old and have been cancer-free for at least five years. The study will involve about 500 participants across several hospitals in France, where they will undergo a hearing test using a specific medical device called the iAudiogram and fill out questionnaires about their experiences with hearing and cancer treatments.

To be eligible for this study, participants must have been treated for specific types of cancer, such as brain tumors or leukemia, before turning 25 and must be free of cancer for at least five years. Pregnant or breastfeeding women can also participate, and those with certain hearing devices may still join the study by completing the questionnaires. Participants can expect to receive a hearing test and share their experiences, which will help researchers learn more about the effects of cancer treatment on hearing. It’s important to note that this study is not yet recruiting participants, but it aims to gather valuable information to improve care for cancer survivors in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients aged between 18 and 50 years at audiological investigations
• • Treated for brain tumor, solid cancer, lymphoma or leukemia in childhood, adolescence or at a young adult age (\<25years)
• • With at least 5 years of cancer-free follow-up after childhood cancer
• • Patients included in the FCCSS ( https://fccss.fr ) deep cohort of 7670 5-year childhood cancer survivors treated before 2001, or patients who have planned visit in long-term follow-up clinics of Curie Institute and Gustave Roussy, whatever the diagnostic period
• • Pregnant or breast-feeding women can be included as no risk is identified
• • With Social security coverage
• • Signed written informed consent obtained
• • NB: Patients included in another research project are not excluded from this one
• • NB: patients wearing a Lyric hearing prosthesis or any other permanent hearing prosthesis or cochlear implant can be included in the study but will not perform audiological examinations because the audiogram can't be easily performed without hearing prosthesis. Nevertheless, these patients could participate to the study with self-administered questionnaires and could be included as cases (i.e. patients with hearing deficiency) in analyses.
• Exclusion Criteria:
• • Patient under guardianship or deprived of his liberty by a judicial or administrative decision or incapable of giving its consent
• • Patient with unavailable data concerning treatment modalities including cumulative doses of chemotherapy agents or radiation fields and dose