Clinical Study to Evaluate the Tooth Whitening Efficacy

Launched by COLGATE PALMOLIVE · Apr 26, 2025

Keywords

ClinConnect Summary

This clinical trial is focused on testing the effectiveness of a new toothpaste called Optic White, which contains 5% hydrogen peroxide, compared to Crest 3D White toothpaste that has no hydrogen peroxide. The main goal is to see how well each toothpaste can whiten teeth over one week. The study is currently looking for participants aged 18 to 70 who are in good overall and oral health, have all their front teeth, and have teeth that are a certain shade or darker.

Participants in this trial can expect to use one of the two toothpastes for a week and report their experiences. It's important to know that some people may not be eligible to join, especially those with certain dental issues, those who have had professional whitening treatments recently, or those who are pregnant or breastfeeding. If you meet the criteria, this could be a great opportunity to help researchers learn more about tooth whitening products!

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Signed Informed Consent Form;
• • Male and female subjects 18-70 years old, inclusive;
• • Good general health and good oral health based on the opinion of the study investigator;
• • All maxillary natural permanent anterior teeth (6-11) must be present;
• • Availability for the duration of the study;
• • Minimum average Vita Extended Bleachedguide 3D-Master shade score of 17 ≥ or darker.
• Exclusion Criteria:
• • Presence of orthodontic appliances and/or any anterior tooth with a prosthetic crown, veneer, or deemed non-vital;
• • Obvious signs of periodontal disease, rampant caries, or any condition that the dental examiner considers exclusionary from the study;
• • Five or more carious lesions requiring immediate care;
• • Concurrent participation in another clinical study;
• • Self-reported pregnant and/or lactating women;
• • History of allergies or sensitivity to tooth whitening products, hydrogen peroxide, personal care consumer products, or their ingredients;
• • Restorations on the teeth to be scored which may interfere with scoring procedures;
• • Have used a professional whitening product within one (1) year and/or had a dental prophylaxis (professional dental cleaning) within thirty (30) days prior to the start of the study