The Comparison of Navigational Bronchoscopic and CT-Guided Preoperative Markings in Minimally Invasive Thoracic Surgery

Launched by SEMMELWEIS UNIVERSITY · Apr 26, 2025

Keywords

ClinConnect Summary

This clinical trial is designed to compare two methods for marking small lung nodules before minimally invasive surgery, known as VATS (Video-Assisted Thoracoscopic Surgery). The researchers want to find out if a newer technique called navigational bronchoscopy, which uses a special green dye that shows up on a screen, works better than the traditional CT-guided method that uses a radioactive substance. The goal is to see which method helps the surgeon locate the nodules more quickly and whether the new method reduces the chances of not removing the entire nodule during surgery.

To be part of this trial, participants should be between 18 and 85 years old and have lung nodules that are 1-3 centimeters in size. They will undergo a special marking procedure before their scheduled surgery and will have a follow-up visit three weeks later for checkups. It's important to note that individuals who have had prior thoracic surgery or are on long-term steroids may not be eligible to participate. This trial is currently not recruiting participants, but it aims to improve surgical outcomes for patients with lung nodules.

Gender

ALL

Eligibility criteria

• • In this study, patients with lung nodules between 10 and 30 mm (under clinical IC or lower stage if it was a case of NSCLC) who are fit for surgery will be enrolled. The investigators will collect epidemiological data, including age, race, gender, Charlson Comorbidity Index, smoking history, medications taken, previous surgeries, significant diseases, BMI, and detailed parameters of the radiological size of the tumor preoperatively. Within two months before surgery, the investigators will conduct a contrast-enhanced chest CT, which will include the upper abdomen and lung function tests (FVC, FEV1, DLCO). Patients who had previous thoracic surgery, are under 18 or over 85 years of age, or have FVC or FEV1 less than 60% will be excluded. Any patient unsuitable for the complete preoperative diagnostic procedure will also be excluded (for example, where contrast material is contraindicated in chronic kidney failure). Pathological parameters of the lesion will be evaluated within four weeks after surgery. Imaging will be conducted at least during the one-month follow-up to monitor complications.
• Summary:
• Inclusion Criteria:
• • Aged from 18 to 85
• • 1-3 cm lung nodules
• • planned procedure VATS uniportal diagnostic wedge
• Exclusion Criteria:
• • Previous thoracic surgery
• • CCI greater than 12
• • Long-term steroid treatment