Neuroimmunology Registry and Biobank

Launched by CHARITE UNIVERSITY, BERLIN, GERMANY · May 3, 2025

Keywords

ClinConnect Summary

The Neuroimmunology Registry and Biobank is a clinical trial that aims to understand the role of certain antibodies found in the cerebrospinal fluid (the fluid surrounding the brain and spinal cord) of patients with various neurological disorders. These disorders include conditions like encephalopathy (brain dysfunction), psychosis, epilepsy, and movement disorders. The researchers want to find out if these antibodies are more common in these diseases than previously thought and whether they are important for causing these conditions or if they are just a byproduct of inflammation in the brain. They will collect and analyze samples from many patients to answer these questions.

Anyone who might be experiencing unclear neurological symptoms, where a lumbar puncture (a procedure to collect cerebrospinal fluid) is needed for further diagnosis, may be eligible to participate in this study. Participants of all ages and genders are welcomed, as long as they can provide a small additional sample of cerebrospinal fluid. By joining this trial, participants can help researchers learn more about these antibodies and how they relate to their conditions, which could lead to better treatment options in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Differential diagnosis: suspected neuroimmunological disease in which a lumbar puncture is indicated for further diagnosis and treatment decision
• • 2. Individuals with unclear clinical diagnosis where additional CSF is to be collected for isolation of B cells and production of monoclonal antibodies. The clinical condition of the patients and his/her compliance have to allow an extra 2-3 ml of CSF to be collected.
• • 3. Age: all age groups
• • 4. Gender: patients of both sexes will be included
• Exclusion criteria:
• • \[1\] Withdrawal of consent