Neural Mechanism of Cerebrocardiac Syndrome Following Traumatic Brain Injury

Launched by SHANGHAI 6TH PEOPLE'S HOSPITAL · May 3, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a serious condition called cerebrocardiac syndrome (CCS) that can occur after a traumatic brain injury (TBI). CCS can lead to heart problems like injury to the heart muscle, irregular heartbeats, or heart failure, especially within the first week after the injury. Researchers believe that issues with the body’s nervous system may trigger CCS after a TBI, but they want to understand exactly how this happens. By using MRI scans, the study aims to identify the brain areas that may be linked to the development of CCS, which could help in finding better ways to prevent and treat this condition.

To participate in the trial, individuals must be between 18 and 80 years old and have experienced a mild to moderate TBI, meaning their injury is not severe enough to put them in a coma (a Glasgow Coma Scale score of 9-15). Participants should be admitted to the hospital within 24 hours of their injury and must agree to take part in the study by signing a consent form. Those with a history of serious heart problems or other major health issues related to their brain or heart may not be eligible. Throughout the study, participants will undergo MRI or fMRI scans to help researchers better understand the links between brain injuries and heart conditions following a TBI.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients with isolated closed head trauma
• • Age 18-80 years old
• • Admitted to hospital within 24 hours of injury
• • Mild or moderate TBI (Glasgow Coma Scale score of 9-15)
• • Signed consent form
• Exclusion Criteria:
• • Severe TBI (Glasgow Coma Scale score of 3-8)
• • A history of stroke, TBI, intracranial tumor or surgery in the past 1 year
• • A history of coronary heart disease, structural heart disease and other primary heart diseases or suspected cardiac symptoms prior to injury
• • Causes of abnormal cardiac biomarkers such as renal insufficiency, severe anemia, sepsis, cardiotoxic drugs and so on
• • Not suitable for MRI examinations, such as pregnant women and those with metal implants in the body
• • Undergo surgery prior to MRI examinations or cardiac testing