Adjunctive Effect of Erythritol on Pocket Closure Rates

Launched by UNIVERSITY OF L'AQUILA · Apr 25, 2025

Keywords

ClinConnect Summary

This clinical trial is investigating whether adding erythritol powder to standard deep cleaning treatment can help improve gum health for people suffering from severe periodontitis, a serious gum disease. Participants in the study will either receive the usual treatment or the usual treatment along with cleaning using erythritol powder. The main goal is to see if using erythritol leads to better healing of gum pockets, less bleeding, lower plaque levels, and improved gum attachment compared to just the standard treatment.

To be eligible for the trial, participants must be adults aged 18 and older, diagnosed with advanced periodontitis, and have at least 12 natural teeth with gum pockets that are 4 mm deep or more. Good general health is important, but certain conditions like recent antibiotic use, pregnancy, or smoking heavily may exclude someone from participating. If you join this trial, you'll receive either the standard treatment or the enhanced treatment with erythritol, and you’ll be monitored to see how well your gums respond to the treatment.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adults aged 18 years or older
• • Diagnosed with stage 3 or 4 periodontitis according to the 2017 classification
• • Presence of at least 12 natural teeth
• • Presence of periodontal pockets with probing depth ≥ 4 mm in non-adjacent teeth
• • Good general health or stable systemic conditions (e.g., controlled diabetes)
• Exclusion Criteria:
• • Use of antibiotics or anti-inflammatory drugs within 3 months prior to treatment
• • Periodontal treatment in the previous 6 months
• • Pregnancy or breastfeeding
• • Current smokers of more than 10 cigarettes per day
• • Allergies or intolerance to erythritol or any materials used in the treatment
• • Systemic diseases or conditions that could influence periodontal healing (e.g., uncontrolled diabetes, immunodeficiency)
• • Use of medications known to affect periodontal tissues (e.g., phenytoin, cyclosporine, calcium channel blockers)