Antibacterial Efficacy and Outcomes of Root Canal Irrigation Methods

Launched by NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS · Apr 28, 2025

Keywords

ClinConnect Summary

This randomized, two-arm, parallel clinical trial investigates the antibacterial effectiveness and clinical outcomes of three root canal final irrigation protocols in teeth with pulp necrosis and apical periodontitis. Following standard chemomechanical preparation, participants' teeth will be randomly assigned to one of three interventions: final irrigation with 2.5% sodium hypochlorite alone, sodium hypochlorite activated by Passive Ultrasonic Irrigation (PUI) or sodium hypochlorite activated with the XP-Endo Finisher file.

The study focuses on the reduction of total bacterial load and sp...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Informed consent by the patients who wish to participate in the study.
• • Single-rooted teeth with pulp necrosis confirmed by pulp sensibility tests, negative response to both cold and electric pulp testing and radiographic evidence of apical periodontitis.
• • Teeth with relatively straight canals, complete root development and no radiographic evidence of pulp canal obliteration.
• Exclusion Criteria:
• • Patients who have received antibiotic treatment the last 3 months or need chemoprophylaxis for dental treatment.
• • Teeth with previous endodontic treatment.
• • Teeth with cracks or incomplete vertical root fracture which disturbs the integrity of the pulp chamber walls or teeth with the pulp chamber exposed to oral environment.
• • Teeth with periodontal pocket more than 4mm.