The Diagnostic Value of Serum Oncostatin M and Galactin 3 as Biomarkers in Diagnosis of Ulcerative Colitis Disease

Launched by SOHAG UNIVERSITY · Apr 28, 2025

Keywords

ClinConnect Summary

This clinical trial is studying two substances in the blood called Oncostatin M and Galectin 3 to see if they can help doctors diagnose ulcerative colitis (UC) more accurately. Ulcerative colitis is a long-term condition that causes inflammation in the colon, leading to symptoms like abdominal pain and diarrhea. The researchers want to compare these blood markers between healthy individuals and patients who have recently been diagnosed with UC, to better understand their role in identifying this disease.

To participate in the trial, you need to be over 18 years old and have a confirmed diagnosis of ulcerative colitis. The study will include both healthy volunteers and patients with UC, who will be classified based on the severity of their symptoms. If you join, you can expect to answer questions about your bowel habits and general health, which will help assess the severity of your condition. It's important to note that people with certain other health issues, like rheumatoid arthritis or cancer, won't be eligible to participate. This trial aims to improve the understanding and diagnosis of ulcerative colitis, which could ultimately lead to better care for patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients, both male and female, who are over the age of 18 and were identified as having ulcerative colitis based on histological, clinical, and endoscopic criteria.
• • Group I The study group will include 40 normal healthy subject. Group II The study group will include 50 patients newly diagnosed with confirmed ulcerative colitis who divided into active and non active.
• Ulcerative colitis activity diagnosed by Simple Clinical Colitis Activity Index (SCCAI) is a diagnostic tool and questionnaire used to assess the severity of symptoms in people who suffer from ulcerative colitis(Walmsley et al.,1998). The calculated score ranges from 0 to20, where active disease is a score of 5 or higher. The score is determined by asking the person with colitis questions regarding:
• • Bowel frequency at day/night Urgency of defecation Blood in stool General health Extracolonic manifestations
• Exclusion Criteria:
• • Those with concomitant systemic inflammation as Rheumatoid arthritis(RA) and Bronchial asthma (BA), those with a history of malignancy, Also, patients who were discovered to have autoimmune disease or microscopic colitis and Crohn's disease, ulcerative colitis patients who are on treatment.