Exercise-based Frailty Intervention in Lung Transplantation (XFIT)

Launched by UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · Apr 28, 2025

Keywords

ClinConnect Summary

The XFIT study is looking at a new program that combines exercise and behavioral training delivered through telehealth to help lung transplant candidates who are frail. The main goals of this study are to see if the program is safe, if people find it easy to participate in, and if it actually helps improve their strength and overall physical ability. Participants will either take part in the 8-week XFIT program or receive standard care.

To join the study, participants need to be between 18 and 75 years old, speak either English or Spanish, and be on a certain level of oxygen support during a walking test. They should also have a specific score on a physical performance test. However, people who live alone, have a very low body weight, or are already in a rehabilitation program may not be eligible. This study is not yet recruiting participants, but it aims to provide important insights into how exercise can benefit those preparing for a lung transplant.

Gender

ALL

Eligibility criteria

• • Group 1
• Inclusion Criteria:
• • Age 18 - 65 years
• • Lung Transplant Candidates
• • Speaks English or Spanish
• • ≤ 8LPM O2 on 6MWT
• • SPPB score ≤ 10
• Exclusion Criteria:
• • Lives Alone
• • BMI \< 18.0 kg/m2
• • Engaged in clinical pulmonary rehabilitation program
• • Severe pHTN (RHC mPAP ≥ 30 mmHg or TTE PASP ≥ 60mmHg or moderately/severely reduced RV systolic function on TTE
• • Deemed unsafe by site PI
• • Group 2
• Inclusion Criteria:
• • Age 18 - 75 years
• • Speaks English or Spanish
• • ≤ 15LPM O2 on 6MWT
• • SPPB score ≤ 10
• Exclusion Criteria:
• • Lives Alone
• • BMI \< 18.0 kg/m2
• • Engaged in clinical pulmonary rehabilitation program
• • Severely reduced RV systolic function on TTE
• • Deemed unsafe by site PI